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    Dmpk DM1 protein kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dmpkprovided by RGD
    Official Full Name
    DM1 protein kinaseprovided by RGD
    Primary source
    RGD:1309825
    See related
    EnsemblRapid:ENSRNOG00000015085 AllianceGenome:RGD:1309825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dm15
    Summary
    Predicted to enable ATP binding activity; myosin phosphatase regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including muscle cell apoptotic process; regulation of skeletal muscle contraction by calcium ion signaling; and regulation of synapse structural plasticity. Predicted to act upstream of or within regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction and regulation of sodium ion transport. Predicted to be located in several cellular components, including bounding membrane of organelle; cytosol; and nuclear membrane. Human ortholog(s) of this gene implicated in myotonic dystrophy type 1. Orthologous to human DMPK (DM1 protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 649.4), Heart (RPKM 490.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmpk in Genome Data Viewer
    Location:
    1q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87858294..87868624)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78730255..78740585)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (79988096..79999358)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene jupiter microtubule associated homolog 1-like Neighboring gene radial spoke head 6 homolog A Neighboring gene uncharacterized LOC108349062 Neighboring gene DM1 locus, WD repeat containing Neighboring gene SIX homeobox 5 Neighboring gene meiosis initiator Neighboring gene F-box protein 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Myotonic dystrophy CTG repeat expansion alters Ca2+ channel functional expression in PC12 cells. Andrade A, et al. FEBS Lett, 2007 Sep 18. PMID 17719582
    2. The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy. Damanafshan A, et al. Cardiovasc Res, 2018 Sep 1. PMID 29648621
    3. A role for myotonic dystrophy protein kinase in synaptic plasticity. Schulz PE, et al. J Neurophysiol, 2003 Mar. PMID 12612014
    4. Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition. Bush EW, et al. Biochemistry, 2000 Jul 25. PMID 10913253
    5. Myotonic dystrophy protein kinase is involved in the modulation of the Ca2+ homeostasis in skeletal muscle cells. Benders AA, et al. J Clin Invest, 1997 Sep 15. PMID 9294109, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MEF2-induced loss of sarcomeres is mediated by DMPK via a decrease in sarcomeric gene expression by interfering with SRF transcriptional activity, leading to adverse cardiomyocyte remodelling and heart failure.
      Title: The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy.
    2. DMPK peptides were identified by high-resolution mass spectrometry together with several putative DMPK-binding proteins, including several heat shock proteins such as HSP20/HSPB6, HSP60/CPN60, HSP70 and HSP90.
      Title: Mass spectrometry analysis of complexes formed by myotonic dystrophy protein kinase (DMPK).
    3. Data suggest modifications in the processing of N-type Ca(2+) channels in PC12 cells expressing the DM1 mutation.
      Title: Myotonic dystrophy CTG repeat expansion alters Ca2+ channel functional expression in PC12 cells.
    4. DMPK phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum
      Title: Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heart contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of skeletal muscle contraction by calcium ion signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of skeletal muscle contraction by calcium ion signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse structural plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myotonin-protein kinase
    Names
    dystrophia myotonica kinase, B15
    dystrophia myotonica-protein kinase
    NP_001358993.1
    NP_001402776.1
    NP_001402777.1
    NP_001402778.1
    XP_008757271.1
    XP_017445484.1
    XP_038967160.1
    XP_038967163.1
    XP_038967182.1
    XP_038967184.1
    XP_038967186.1
    XP_063117378.1
    XP_063117379.1
    XP_063117382.1
    XP_063117383.1
    XP_063117389.1
    XP_063117390.1
    XP_063117394.1
    XP_063117399.1
    XP_063117400.1
    XP_063117402.1
    XP_063117403.1
    XP_063117406.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372064.1 → NP_001358993.1  myotonin-protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      FQ235737, JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZYV4
      Related
      ENSRNOP00000020428.9, ENSRNOT00000020428.10
      Conserved Domains (2) summary
      pfam08826
      Location:472 → 532
      DMPK_coil; DMPK coiled coil domain like
      cl21453
      Location:69 → 406
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001415847.1 → NP_001402776.1  myotonin-protein kinase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J8J5

    3. NM_001415848.1 → NP_001402777.1  myotonin-protein kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZYV4
      Related
      ENSRNOP00000067795.3, ENSRNOT00000071916.5

    4. NM_001415849.1 → NP_001402778.1  myotonin-protein kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J8J5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      87858294..87868624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261309.1 → XP_063117379.1  myotonin-protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I6ANX6
      Related
      ENSRNOP00000109310.1, ENSRNOT00000150391.1

    2. XM_063261308.1 → XP_063117378.1  myotonin-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANX6
      Related
      ENSRNOP00000095056.2, ENSRNOT00000105612.2

    3. XM_039111254.1 → XP_038967182.1  myotonin-protein kinase isoform X10

      UniProtKB/TrEMBL
      A6J8J5
      Conserved Domains (2) summary
      pfam08826
      Location:472 → 532
      DMPK_coil; DMPK coiled coil domain like
      cl21453
      Location:69 → 406
      PKc_like; Protein Kinases, catalytic domain

    4. XM_039111232.1 → XP_038967160.1  myotonin-protein kinase isoform X5

      UniProtKB/TrEMBL
      A0A8I6ANX6
      Conserved Domains (2) summary
      pfam08826
      Location:472 → 532
      DMPK_coil; DMPK coiled coil domain like
      cl21453
      Location:69 → 406
      PKc_like; Protein Kinases, catalytic domain

    5. XM_039111256.2 → XP_038967184.1  myotonin-protein kinase isoform X13

      UniProtKB/TrEMBL
      A6J8J5
      Conserved Domains (3) summary
      pfam08826
      Location:472 → 532
      DMPK_coil; DMPK coiled coil domain like
      NF033885
      Location:439 → 566
      conj_TraP_IncI1; conjugal transfer protein TraP
      cl21453
      Location:69 → 406
      PKc_like; Protein Kinases, catalytic domain

    6. XM_017589995.2 → XP_017445484.1  myotonin-protein kinase isoform X8

      UniProtKB/TrEMBL
      D3ZYV4

    7. XM_063261313.1 → XP_063117383.1  myotonin-protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8I6ANX6

    8. XM_063261312.1 → XP_063117382.1  myotonin-protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I6ANX6

    9. XM_063261324.1 → XP_063117394.1  myotonin-protein kinase isoform X11

      UniProtKB/TrEMBL
      A6J8J5

    10. XM_039111235.1 → XP_038967163.1  myotonin-protein kinase isoform X6

      UniProtKB/TrEMBL
      A0A8I6ANX6
      Conserved Domains (2) summary
      pfam08826
      Location:467 → 527
      DMPK_coil; DMPK coiled coil domain like
      cl21453
      Location:69 → 401
      PKc_like; Protein Kinases, catalytic domain

    11. XM_063261329.1 → XP_063117399.1  myotonin-protein kinase isoform X15

      UniProtKB/TrEMBL
      A6J8J5

    12. XM_063261320.1 → XP_063117390.1  myotonin-protein kinase isoform X9

      UniProtKB/TrEMBL
      D3ZYV4

    13. XM_063261330.1 → XP_063117400.1  myotonin-protein kinase isoform X16

      UniProtKB/TrEMBL
      A6J8J5

    14. XM_063261319.1 → XP_063117389.1  myotonin-protein kinase isoform X7

      UniProtKB/TrEMBL
      A0A8I6ANX6

    15. XM_008759049.3 → XP_008757271.1  myotonin-protein kinase isoform X12

      See identical proteins and their annotated locations for XP_008757271.1

      UniProtKB/TrEMBL
      A6J8J5
      Conserved Domains (3) summary
      pfam08826
      Location:472 → 532
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71 → 339
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:69 → 406
      PKc_like; Protein Kinases, catalytic domain

    16. XM_039111258.1 → XP_038967186.1  myotonin-protein kinase isoform X14

      UniProtKB/TrEMBL
      A6J8J5
      Conserved Domains (2) summary
      pfam08826
      Location:472 → 532
      DMPK_coil; DMPK coiled coil domain like
      cl21453
      Location:69 → 406
      PKc_like; Protein Kinases, catalytic domain

    17. XM_063261336.1 → XP_063117406.1  myotonin-protein kinase isoform X19

      UniProtKB/TrEMBL
      D3ZYV4

    18. XM_063261333.1 → XP_063117403.1  myotonin-protein kinase isoform X18

    19. XM_063261332.1 → XP_063117402.1  myotonin-protein kinase isoform X17

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107484.1: Suppressed sequence

      Description
      NM_001107484.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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