Rem2 RRAD and GEM like GTPase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rem2provided by RGD
Official Full Name: RRAD and GEM like GTPase 2provided by RGD
Primary source: RGD:69081
See related: EnsemblRapid:ENSRNOG00000011646 AllianceGenome:RGD:69081
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTP binding activity and GTPase activity. Predicted to be involved in negative regulation of high voltage-gated calcium channel activity. Predicted to be active in plasma membrane. Orthologous to human REM2 (RRAD and GEM like GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 24.2), Kidney (RPKM 21.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (31903972..31908451)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (27933950..27938429)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33121273..33125752)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits.
Title: Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits.
When rats become maternal, they increase the expression of Rem2 in the medial preoptic area which inhibits dendritic complexity and associates with an enhancement of maternal responsiveness.
Title: Maternal care associates with differences in morphological complexity in the medial preoptic area.
Rem2 is regulated at the transcriptional level by calcium influx and inhibits dendritic arborization in cultured rat cortical neurons
Title: Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo.
Rem2 has a role in neuronal plasticity hrough co-trafficking with CaMKIIa
Title: Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIα.
structure of the Rem2 G domain bound to GDP is reported here in a monoclinic crystal form at 2.66 A resolution
Title: Structure of the GDP-bound G domain of the RGK protein Rem2.
molecular mechanisms by which Rem2 knockdown affected synaptogenesis and Ca(2) homeostasis in cultured rat hippocampal neurons
Title: Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.
our results suggest that Rem2 regulates dendritic branching and synapse development
Title: The GTPase Rem2 regulates synapse development and dendritic morphology.
Voltage dependant calcium channels blockade by Rem2 is likely to be controlled by both the localized concentration of membrane phosphorylated phosphatidylinositide lipids and direct 14-3-3 binding to the Rem2 C-terminus.
Title: Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids.
Rem2 localizes to the plasma membrane via a C-terminal motif and interacts with calcium channel beta subunits in the preassembled N-type channel, thereby forming a nonconducting species.
Title: Expression of Rem2, an RGK family small GTPase, reduces N-type calcium current without affecting channel surface density.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GTP-binding protein REM 2

Names: GEM, REM, Kir family small G-protein; GTP-binding protein REM2; RAS (RAD and GEM) like GTP binding 2; Ras-related GTP-binding protein of the Rad/Gem/Kir family, member 2; rad and Gem-like GTP-binding protein 2; rad and gem related GTP binding protein 2

NP_073176.2

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.