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    Cacul1 CDK2-associated, cullin domain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365493, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cacul1provided by RGD
    Official Full Name
    CDK2-associated, cullin domain 1provided by RGD
    Primary source
    RGD:1308127
    See related
    EnsemblRapid:ENSRNOG00000009954 AllianceGenome:RGD:1308127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308127
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. Orthologous to human CACUL1 (CDK2 associated cullin domain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 152.2), Lung (RPKM 150.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cacul1 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (269652356..269712265, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (259666335..259726249, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (281814226..281874675, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 88 Neighboring gene prolactin releasing hormone receptor Neighboring gene small nuclear ribonucleoprotein 13, pseudogene 5 Neighboring gene uncharacterized LOC108349715 Neighboring gene uncharacterized LOC134485267

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of CAC1 as a novel CDK2-associated cullin. Kong Y, et al. Cell Cycle, 2009 Nov 1. PMID 19829063
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDK2-associated and cullin domain-containing protein 1
    Names
    uncharacterized protein C10orf46 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014248.2 → NP_001014270.1  CDK2-associated and cullin domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001014270.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5XI53
      UniProtKB/TrEMBL
      A6JIA4
      Related
      ENSRNOP00000051311.2, ENSRNOT00000050617.5
      Conserved Domains (1) summary
      pfam00888
      Location:146 → 278
      Cullin; Cullin family

    2. NM_001416001.1 → NP_001402930.1  CDK2-associated and cullin domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K1Y0, A6JIA4
      Related
      ENSRNOP00000072029.1, ENSRNOT00000084760.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      269652356..269712265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085812.2 → XP_038941740.1  CDK2-associated and cullin domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A6JIA4
      Related
      ENSRNOP00000089369.1, ENSRNOT00000109460.2

    2. XM_039085806.2 → XP_038941734.1  CDK2-associated and cullin domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6JIA4
      Conserved Domains (1) summary
      pfam00888
      Location:145 → 269
      Cullin; Cullin family

    3. XM_063270019.1 → XP_063126089.1  CDK2-associated and cullin domain-containing protein 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI53.1 GenPept UniProtKB/Swiss-Prot:Q5XI53

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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