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    Taf6l TATA-box binding protein associated factor 6 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taf6lprovided by RGD
    Official Full Name
    TATA-box binding protein associated factor 6 likeprovided by RGD
    Primary source
    RGD:1310123
    See related
    EnsemblRapid:ENSRNOG00000019419 AllianceGenome:RGD:1310123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; regulation of DNA-templated transcription; and regulation of somatic stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of SAGA complex. Orthologous to human TAF6L (TATA-box binding protein associated factor 6 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 64.4), Thymus (RPKM 52.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Taf6l in Genome Data Viewer
    Location:
    1q43
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215101266..215113888, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205672147..205684721, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224974238..224986819, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 223 Neighboring gene transmembrane protein 179B Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene RNA polymerase II subunit G Neighboring gene zinc finger and BTB domain containing 3 Neighboring gene tetratricopeptide repeat domain 9C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Seruggia D, et al. Mol Cell, 2019 Jun 20. PMID 31005419, Free PMC Article
    2. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Martinez E, et al. Mol Cell Biol, 2001 Oct. PMID 11564863, Free PMC Article
    3. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article
    4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SLIK (SAGA-like) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
    Names
    TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107575.1 → NP_001101045.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

      See identical proteins and their annotated locations for NP_001101045.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
      Conserved Domains (2) summary
      pfam02969
      Location:16 → 80
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:160 → 372
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215101266..215113888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230982.5 → XP_006231044.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

      See identical proteins and their annotated locations for XP_006231044.1

      UniProtKB/TrEMBL
      A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
      Conserved Domains (2) summary
      pfam02969
      Location:16 → 80
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:160 → 372
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    2. XM_008760224.4 → XP_008758446.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

      See identical proteins and their annotated locations for XP_008758446.1

      UniProtKB/TrEMBL
      A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
      Conserved Domains (2) summary
      pfam02969
      Location:16 → 80
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:160 → 372
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    3. XM_006230981.5 → XP_006231043.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

      See identical proteins and their annotated locations for XP_006231043.1

      UniProtKB/TrEMBL
      A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
      Conserved Domains (2) summary
      pfam02969
      Location:16 → 80
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:160 → 372
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    4. XM_039079710.2 → XP_038935638.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
      Conserved Domains (2) summary
      pfam02969
      Location:16 → 80
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:160 → 372
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    5. XM_006230979.5 → XP_006231041.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

      See identical proteins and their annotated locations for XP_006231041.1

      UniProtKB/TrEMBL
      A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
      Related
      ENSRNOP00000026284.6, ENSRNOT00000026284.9
      Conserved Domains (2) summary
      pfam02969
      Location:16 → 80
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:160 → 372
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    6. XM_017589259.3 → XP_017444748.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
      Conserved Domains (2) summary
      pfam02969
      Location:16 → 80
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:160 → 372
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    7. XM_039079711.2 → XP_038935639.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
      Conserved Domains (2) summary
      pfam02969
      Location:16 → 80
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:160 → 372
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    8. XM_063264420.1 → XP_063120490.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938

    9. XM_039079714.2 → XP_038935642.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X2

      Conserved Domains (2) summary
      pfam02969
      Location:16 → 80
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:160 → 370
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
    Nucleotide Protein Strain
    Heading Accession and Version

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