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    Fhod3 formin homology 2 domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fhod3provided by RGD
    Official Full Name
    formin homology 2 domain containing 3provided by RGD
    Primary source
    RGD:2322319
    See related
    EnsemblRapid:ENSRNOG00000027230 AllianceGenome:RGD:2322319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within sarcomere organization. Located in striated muscle thin filament. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human FHOD3 (formin homology 2 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007906026.1 and NW_007906027.1 in NCBI's Rattus norvegicus Annotation Release 105. [19 Jun 2015]
    Expression
    Biased expression in Heart (RPKM 565.8), Muscle (RPKM 151.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fhod3 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (16267830..16700508)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (15993079..16425796)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (16650786..17332209)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 2 Neighboring gene molybdenum cofactor sulfurase Neighboring gene uncharacterized LOC120098112 Neighboring gene uncharacterized LOC134482922 Neighboring gene heat shock cognate protein 70, pseudogene 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene tubulin polyglutamylase complex subunit 2 Neighboring gene KIAA1328 homolog Neighboring gene CUGBP, Elav-like family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanical confinement triggers glioma linear migration dependent on formin FHOD3. Monzo P, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912794, Free PMC Article
    2. Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis. Kan-O M, et al. Biol Open, 2012 Sep 15. PMID 23213483, Free PMC Article
    3. Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heart. Kan-o M, et al. PLoS One, 2012. PMID 22509354, Free PMC Article
    4. Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles. Taniguchi K, et al. J Biol Chem, 2009 Oct 23. PMID 19706596, Free PMC Article
    5. Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor. Arimura T, et al. Circ J, 2013. PMID 24088304

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FHOD3 played a role in glioma linear migration.
      Title: Mechanical confinement triggers glioma linear migration dependent on formin FHOD3.
    2. DCM-associated FHOD3 variant may cause DCM by interfering with actin filament assembly.
      Title: Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor.
    3. Following myofibril disassembly, such as that in dedifferentiating adult rat cardiomyocytes in culture, the expression of non-muscle Fhod3 is up-regulated, which is reversed once the myofibrils are reassembled.
      Title: Two distinct phosphorylation events govern the function of muscle FHOD3.
    4. actin dynamics regulated by Fhod3 are critical for sarcomere organization in striated muscle cells.
      Title: Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cardiac myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FH1/FH2 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271332.3 → NP_001258261.3  FH1/FH2 domain-containing protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6J2L1, F1LQJ2

    2. NM_001415718.1 → NP_001402647.1  FH1/FH2 domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I5ZR39, A6J2L1
      Related
      ENSRNOP00000080632.1, ENSRNOT00000102032.2

    3. NM_001415719.1 → NP_001402648.1  FH1/FH2 domain-containing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6J2L1

    4. NM_001415720.1 → NP_001402649.1  FH1/FH2 domain-containing protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6J2L1, F1LRX2
      Related
      ENSRNOP00000061693.3, ENSRNOT00000068139.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      16267830..16700508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600804.3 → XP_017456293.1  FH1/FH2 domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q6D5, A6J2L1
      Related
      ENSRNOP00000076213.2, ENSRNOT00000093679.3

    2. XM_017600806.3 → XP_017456295.1  FH1/FH2 domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A6J2L1

    3. XM_063277043.1 → XP_063133113.1  FH1/FH2 domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A1W2Q659, A6J2L1
      Related
      ENSRNOP00000076142.2, ENSRNOT00000093285.3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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