Iqgap3 IQ motif containing GTPase activating protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Iqgap3provided by RGD
Official Full Name: IQ motif containing GTPase activating protein 3provided by RGD
Primary source: RGD:1305951
See related: EnsemblRapid:ENSRNOG00000027894 AllianceGenome:RGD:1305951
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including GTPase activator activity; calmodulin binding activity; and cytoskeletal protein binding activity. Predicted to be involved in mitotic actomyosin contractile ring assembly actin filament organization. Predicted to act upstream of or within several processes, including G1/S transition of mitotic cell cycle; intracellular signaling cassette; and regulation of gene expression. Predicted to be located in cell-cell junction; cytoplasm; and lateral plasma membrane. Predicted to be active in cell cortex. Orthologous to human IQGAP3 (IQ motif containing GTPase activating protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 35.3), Thymus (RPKM 30.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (175840001..175881799)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (173542151..173583956)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (187447477..187489630)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Naturally occurring cytokinesis failure in primary cardiomyocytes is due to an aberrant mitotic microtubule apparatus and mislocalization of RhoA and IQGAP3 resulting in inefficient anchorage of the actomyosin ring to the plasma cell membrane.
Title: Cardiomyocyte binucleation is associated with aberrant mitotic microtubule distribution, mislocalization of RhoA and IQGAP3, as well as defective actomyosin ring anchorage and cleavage furrow ingression.
Iqgap3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth.
Title: IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables myosin VI light chain binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in mitotic actomyosin contractile ring assembly actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell size	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane bounded cell projection	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras GTPase-activating-like protein IQGAP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191709.1 → NP_001178638.1 ras GTPase-activating-like protein IQGAP3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6AAA8, D3ZCS4

Related

ENSRNOP00000029108.4, ENSRNOT00000038589.7

Conserved Domains (5) summary

smart00015
Location:764 → 782

IQ; Calmodulin-binding motif

smart00323
Location:977 → 1330

RasGAP; GTPase-activator protein for Ras-like GTPases

cd00014
Location:35 → 147

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam03836
Location:1434 → 1555

RasGAP_C; RasGAP C-terminus

cl02569
Location:988 → 1337

RasGAP; Ras GTPase Activating Domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

175840001..175881799

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281833.1 → XP_063137903.1 ras GTPase-activating-like protein IQGAP3 isoform X1

UniProtKB/TrEMBL

A0A8I6AAA8
XM_039102305.2 → XP_038958233.1 ras GTPase-activating-like protein IQGAP3 isoform X2

Conserved Domains (3) summary

COG5022
Location:366 → 589

COG5022; Myosin heavy chain [General function prediction only]

COG5261
Location:493 → 1263

IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

cl02569
Location:619 → 968

RasGAP; Ras GTPase Activating Domain