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    Vezf1 vascular endothelial zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vezf1provided by RGD
    Official Full Name
    vascular endothelial zinc finger 1provided by RGD
    Primary source
    RGD:1308058
    See related
    EnsemblRapid:ENSRNOG00000009819 AllianceGenome:RGD:1308058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of endothelial cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within angiogenesis and endothelial cell development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human VEZF1 (vascular endothelial zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 248.4), Heart (RPKM 163.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vezf1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (73341666..73373320)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72859669..72876111)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (75365763..75382014)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1523 Neighboring gene uncharacterized LOC120095169 Neighboring gene dynein light chain LC8-type 2 Neighboring gene serine and arginine rich splicing factor 1 Neighboring gene CUE domain containing 1 Neighboring gene ribosomal protein L27a, pseudogene 10 Neighboring gene mitochondrial ribosomal protein S23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoter. Aitsebaomo J, et al. J Biol Chem, 2001 Oct 19. PMID 11504723
    2. Inhibition of microRNA-495 Enhances Therapeutic Angiogenesis of Human Induced Pluripotent Stem Cells. Liang J, et al. Stem Cells, 2017 Feb. PMID 27538588
    3. Dosage-dependent requirement for mouse Vezf1 in vascular system development. Kuhnert F, et al. Dev Biol, 2005 Jul 1. PMID 15882861, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endothelial cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vascular endothelial zinc finger 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304355.2 → NP_001291284.1  vascular endothelial zinc finger 1

      See identical proteins and their annotated locations for NP_001291284.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1M8R0
      Related
      ENSRNOP00000078894.2, ENSRNOT00000096619.2
      Conserved Domains (4) summary
      PRK12799
      Location:379 → 496
      motB; flagellar motor protein MotB; Reviewed
      COG5189
      Location:198 → 255
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:174 → 196
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      73341666..73373320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268707.1 → XP_063124777.1  vascular endothelial zinc finger 1 isoform X2

    2. XM_008768166.4 → XP_008766388.1  vascular endothelial zinc finger 1 isoform X1

      See identical proteins and their annotated locations for XP_008766388.1

      UniProtKB/TrEMBL
      A0A8I5ZLS0, F1M8R0
      Conserved Domains (4) summary
      PRK12799
      Location:385 → 502
      motB; flagellar motor protein MotB; Reviewed
      COG5189
      Location:198 → 255
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:174 → 196
      zf-C2H2; Zinc finger, C2H2 type

    3. XM_063268708.1 → XP_063124778.1  vascular endothelial zinc finger 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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