Manea mannosidase, endo-alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Maneaprovided by RGD
Official Full Name: mannosidase, endo-alphaprovided by RGD
Primary source: RGD:620327
See related: EnsemblRapid:ENSRNOG00000008626 AllianceGenome:RGD:620327
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Enman
Summary: Enables alpha-mannosidase activity. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in anxiety disorder; cocaine dependence; and panic disorder. Orthologous to human MANEA (mannosidase endo-alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 107.1), Lung (RPKM 95.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (44992937..45015084, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (40196373..40218540, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (40845103..40867025, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The presence of positively charged amino acids in the cytoplasmic tail is critical for Golgi localization of rat endomannosidase.
Title: Triple arginines in the cytoplasmic tail of endomannosidase are not essential for type II membrane topology and Golgi localization.
We have cloned two novel endomannosidase sequences from rat and human cDNA libraries [and] confirm that endomannosidase is a type II membrane protein, like the majority of other secretory pathway glycosylation enzymes
Title: Intact {alpha}-1,2-endomannosidase is a typical type II membrane protein.
Endomannosidase does not discriminate the folding state og substrate and provides a back-up mechanism for completion of N-glycosylation of endoplasmic reticulum-escaped glucosylated glycoproteins.
Title: Endomannosidase processes oligosaccharides of alpha1-antitrypsin and its naturally occurring genetic variants in the Golgi apparatus.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-mannosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycoprotein endo-alpha-1,2-mannosidase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycoprotein endo-alpha-1,2-mannosidase

Names: endo-alpha mannosidase; endo-alpha-D-mannosidase; endomannosidase; rEndo

NP_542963.2

EC 3.2.1.130

XP_006238023.1

EC 3.2.1.130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.