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    Apbb2 amyloid beta precursor protein binding family B member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305338, updated on 9-Dec-2024

    Summary

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    Symbol
    Apbb2provided by RGD
    Full Name
    amyloid beta precursor protein binding family B member 2provided by RGD
    Primary source
    RGD:1562438
    See related
    EnsemblRapid:ENSRNOG00000063717 AllianceGenome:RGD:1562438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562438
    Summary
    Predicted to enable amyloid-beta binding activity. Predicted to be involved in several processes, including maintenance of lens transparency; negative regulation of cell cycle phase transition; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within extracellular matrix organization; generation of neurons; and regulation of apoptotic process. Predicted to be located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to human APBB2 (amyloid beta precursor protein binding family B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 267.6), Heart (RPKM 236.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Apbb2 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (41849638..42232930)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (41557918..41878622)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43205047..43526968)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene LIM and calponin homology domains 1 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134481847 Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin C-terminal hydrolase L1 Neighboring gene uncharacterized LOC134481846 Neighboring gene NOP2/Sun RNA methyltransferase family member 7 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians. Golanska E, et al. Exp Gerontol, 2013 Apr. PMID 23384821
    2. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Li Y, et al. Hum Mutat, 2005 Mar. PMID 15714520
    3. Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Hsu LJ, et al. Biochem Biophys Res Commun, 2005 Feb 11. PMID 15629131
    4. Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. Bruni P, et al. J Biol Chem, 2002 Sep 20. PMID 12089154
    5. Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. Guénette S, et al. EMBO J, 2006 Jan 25. PMID 16407979, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of lens transparency ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    amyloid beta precursor protein binding family B member 2
    Names
    amyloid beta (A4) precursor protein-binding, family B, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427465.1 → NP_001414394.1  amyloid beta precursor protein binding family B member 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6A9I8
      Related
      ENSRNOP00000088203.1, ENSRNOT00000106751.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      41849638..42232930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273105.1 → XP_063129175.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I8, A0A8I6G7S6

    2. XM_063273114.1 → XP_063129184.1  amyloid beta precursor protein binding family B member 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZYC7

    3. XM_039092527.2 → XP_038948455.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I8, A0A8I6G7S6
      Conserved Domains (3) summary
      cd01271
      Location:583 → 709
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 554
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    4. XM_063273111.1 → XP_063129181.1  amyloid beta precursor protein binding family B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A9I8

    5. XM_039092530.2 → XP_038948458.1  amyloid beta precursor protein binding family B member 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZYC7
      Related
      ENSRNOP00000082727.2, ENSRNOT00000100119.2
      Conserved Domains (3) summary
      cd01271
      Location:562 → 688
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396 → 533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    6. XM_063273115.1 → XP_063129185.1  amyloid beta precursor protein binding family B member 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZYC7
      Related
      ENSRNOP00000084619.2, ENSRNOT00000115068.2

    7. XM_063273113.1 → XP_063129183.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A9I8

    8. XM_039092531.2 → XP_038948459.1  amyloid beta precursor protein binding family B member 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZYC7
      Conserved Domains (3) summary
      cd01271
      Location:561 → 687
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    9. XM_039092532.2 → XP_038948460.1  amyloid beta precursor protein binding family B member 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZYC7
      Conserved Domains (3) summary
      cd01271
      Location:560 → 686
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    10. XM_063273104.1 → XP_063129174.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I8, A0A8I6G7S6

    11. XM_063273103.1 → XP_063129173.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I8, A0A8I6G7S6

    12. XM_063273108.1 → XP_063129178.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I8, A0A8I6G7S6

    13. XM_063273107.1 → XP_063129177.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I8, A0A8I6G7S6

    14. XM_063273109.1 → XP_063129179.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I8, A0A8I6G7S6

    15. XM_063273112.1 → XP_063129182.1  amyloid beta precursor protein binding family B member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A9I8

    16. XM_063273106.1 → XP_063129176.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I8, A0A8I6G7S6

    17. XM_063273102.1 → XP_063129172.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I8, A0A8I6G7S6

    18. XM_063273110.1 → XP_063129180.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9I8, A0A8I6G7S6

    19. XM_063273116.1 → XP_063129186.1  amyloid beta precursor protein binding family B member 2 isoform X9

    20. XM_063273117.1 → XP_063129187.1  amyloid beta precursor protein binding family B member 2 isoform X10

    21. XM_063273120.1 → XP_063129190.1  amyloid beta precursor protein binding family B member 2 isoform X12

    22. XM_063273119.1 → XP_063129189.1  amyloid beta precursor protein binding family B member 2 isoform X11

    23. XM_017599457.3 → XP_017454946.1  amyloid beta precursor protein binding family B member 2 isoform X14

      UniProtKB/TrEMBL
      F1LZU7
      Conserved Domains (1) summary
      cd01271
      Location:34 → 160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

    24. XM_063273122.1 → XP_063129192.1  amyloid beta precursor protein binding family B member 2 isoform X14

    25. XM_063273121.1 → XP_063129191.1  amyloid beta precursor protein binding family B member 2 isoform X13

    Nucleotide Protein Strain
    Heading Accession and Version

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