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    Abhd10 abhydrolase domain containing 10, depalmitoylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303953, updated on 9-Dec-2024

    Summary

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    Symbol
    Abhd10provided by RGD
    Full Name
    abhydrolase domain containing 10, depalmitoylaseprovided by RGD
    Primary source
    RGD:1308084
    See related
    EnsemblRapid:ENSRNOG00000054334 AllianceGenome:RGD:1308084
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308084
    Summary
    Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds and palmitoyl-(protein) hydrolase activity. Predicted to be involved in acyl deglucuronidation and protein depalmitoylation. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human ABHD10 (abhydrolase domain containing 10, depalmitoylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 59.4), Brain (RPKM 50.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abhd10 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (68543860..68556059)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55081273..55095044)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60053719..60068142)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology-like domain, family B, member 2 Neighboring gene uncharacterized LOC102552450 Neighboring gene small nucleolar RNA U13 Neighboring gene transgelin 3 Neighboring gene transmembrane serine protease 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. Iwamura A, et al. J Biol Chem, 2012 Mar 16. PMID 22294686, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mycophenolic acid acyl-glucuronide esterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl deglucuronidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acyl deglucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macromolecule depalmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein depalmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein depalmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyl-protein thioesterase ABHD10, mitochondrial
    Names
    abhydrolase domain-containing protein 10, mitochondrial
    acyl-protein thioesterase ABHD10
    alpha/beta hydrolase domain-containing protein 10, mitochondrial
    mycophenolic acid acyl-glucuronide esterase, mitochondrial
    NP_001116824.1
    XP_008766954.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123352.1 → NP_001116824.1  palmitoyl-protein thioesterase ABHD10, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001116824.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161919
      UniProtKB/Swiss-Prot
      Q5I0K5
      UniProtKB/TrEMBL
      A6IQX5, B1WBW9
      Related
      ENSRNOP00000071368.2, ENSRNOT00000091756.3
      Conserved Domains (1) summary
      COG0596
      Location:56 → 282
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      68543860..68556059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768732.4 → XP_008766954.2  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform X1

      Conserved Domains (1) summary
      COG0596
      Location:56 → 189
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0K5.2 GenPept UniProtKB/Swiss-Prot:Q5I0K5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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