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    Acsm5 acyl-CoA synthetase medium-chain family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acsm5provided by RGD
    Official Full Name
    acyl-CoA synthetase medium-chain family member 5provided by RGD
    Primary source
    RGD:1309578
    See related
    EnsemblRapid:ENSRNOG00000031211 AllianceGenome:RGD:1309578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cc1-38; Aa2-174; RGD1309578
    Summary
    Predicted to enable fatty acid ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ACSM5 (acyl-CoA synthetase medium chain family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1151.3) and Lung (RPKM 64.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acsm5 in Genome Data Viewer
    Location:
    1q35
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183302241..183328175)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173870873..173896838)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189240955..189270422)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycoprotein 2 Neighboring gene uromodulin Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene acyl-CoA synthetase medium-chain family member 2 Neighboring gene RGD1559600 Neighboring gene acyl-CoA synthetase medium-chain family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligase activity, forming carbon-sulfur bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-coenzyme A synthetase ACSM5, mitochondrial
    NP_001014184.3
    XP_006230185.1
    XP_038938781.1
    XP_038938785.1
    XP_038938787.1
    XP_063123652.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014162.5 → NP_001014184.3  acyl-coenzyme A synthetase ACSM5, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001014184.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q6AYT9
      Conserved Domains (1) summary
      cl17068
      Location:48 → 576
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      183302241..183328175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230123.3 → XP_006230185.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006230185.1

      UniProtKB/Swiss-Prot
      Q6AYT9
      Related
      ENSRNOP00000047613.3, ENSRNOT00000046025.6
      Conserved Domains (1) summary
      cl17068
      Location:48 → 576
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. XM_039082853.2 → XP_038938781.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q6AYT9
      Conserved Domains (1) summary
      cl17068
      Location:48 → 576
      AFD_class_I; Adenylate forming domain, Class I superfamily

    3. XM_063267582.1 → XP_063123652.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X2

    4. XM_039082857.2 → XP_038938785.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl17068
      Location:1 → 436
      AFD_class_I; Adenylate forming domain, Class I superfamily

    5. XM_039082859.2 → XP_038938787.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl17068
      Location:1 → 436
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYT9.1 GenPept UniProtKB/Swiss-Prot:Q6AYT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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