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    Crebzf CREB/ATF bZIP transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293112, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crebzfprovided by RGD
    Official Full Name
    CREB/ATF bZIP transcription factorprovided by RGD
    Primary source
    RGD:1565584
    See related
    EnsemblRapid:ENSRNOG00000018987 AllianceGenome:RGD:1565584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565584
    Summary
    Predicted to enable identical protein binding activity and sequence-specific DNA binding activity. Predicted to be involved in negative regulation of gene expression, epigenetic; regulation of DNA-templated transcription; and response to virus. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human CREBZF (CREB/ATF bZIP transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 145.3), Spleen (RPKM 119.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crebzf in Genome Data Viewer
    Location:
    1q32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (153829544..153836073)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (144416864..144423540)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (156290215..156296891, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 2 Neighboring gene coiled-coil domain containing 89 Neighboring gene transmembrane protein 126A Neighboring gene transmembrane protein 126B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mediation of glucolipotoxicity in INS-1 rat insulinoma cells by small heterodimer partner interacting leucine zipper protein (SMILE). Lee KM, et al. Biochem Biophys Res Commun, 2012 Mar 23. PMID 22387546
    2. Zhangfei/CREB-ZF - a potential regulator of the unfolded protein response. Zhang R, et al. PLoS One, 2013. PMID 24155933, Free PMC Article
    3. Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element. Hogan MR, et al. FEBS Lett, 2006 Jan 9. PMID 16343488
    4. Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman. Misra V, et al. J Biol Chem, 2005 Apr 15. PMID 15705566
    5. Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. Lu R, et al. Nucleic Acids Res, 2000 Jun 15. PMID 10871379, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zhangfei had a suppressive effect on most unfolded protein response genes.
      Title: Zhangfei/CREB-ZF - a potential regulator of the unfolded protein response.
    2. These results collectively suggest that SMILE plays an important role in the development of beta cell dysfunction induced by glucolipotoxicity
      Title: Mediation of glucolipotoxicity in INS-1 rat insulinoma cells by small heterodimer partner interacting leucine zipper protein (SMILE).
    3. the curcumin/LKB1/AMPK/SMILE/PGC1alpha pathway differentially regulates ER stress-mediated gene transcription
      Title: Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H).
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CREB/ATF bZIP transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271791.1 → NP_001258720.1  CREB/ATF bZIP transcription factor

      See identical proteins and their annotated locations for NP_001258720.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
      Source sequence(s)
      FN797334, JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6G6F0, A6I638
      Related
      ENSRNOP00000081742.1, ENSRNOT00000104785.2
      Conserved Domains (1) summary
      cl21462
      Location:220 → 261
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RNA

    1. NR_073439.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      JAXUCZ010000001

    2. NR_073440.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      JAXUCZ010000001

    3. NR_073441.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      153829544..153836073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759646.3 → XP_008757868.1  CREB/ATF bZIP transcription factor isoform X1

      See identical proteins and their annotated locations for XP_008757868.1

      UniProtKB/TrEMBL
      A6I636, D3ZU42
      Conserved Domains (1) summary
      cl21462
      Location:220 → 261
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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