Cd200r1 CD200 receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd200r1provided by RGD
Official Full Name: CD200 receptor 1provided by RGD
Primary source: RGD:61837
See related: EnsemblRapid:ENSRNOG00000039048 AllianceGenome:RGD:61837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mox2r
Summary: Enables protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including negative regulation of interleukin-6 production; negative regulation of mononuclear cell migration; and negative regulation of neuroinflammatory response. Located in cell surface. Orthologous to human CD200R1 (CD200 receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 86.2), Liver (RPKM 47.7) and 8 other tissues See more
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Genomic context

Location:: 11q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (69392943..69427213, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (55886937..55921217, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (60848161..60882470, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats.
Title: Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats.
PPAR-gamma promotes the polarization of rat retinal microglia to M2 phenotype by regulating the expression of CD200-CD200R1 under hypoxia.
Title: PPAR-γ promotes the polarization of rat retinal microglia to M2 phenotype by regulating the expression of CD200-CD200R1 under hypoxia.
Involvement of orexin-2 receptors in the CA1 region of the hippocampus in the extinction and reinstatement of methamphetamine-induced conditioned place preference in the rats.
Title: Involvement of orexin-2 receptors in the CA1 region of the hippocampus in the extinction and reinstatement of methamphetamine-induced conditioned place preference in the rats.
Specificity of CD200/CD200R pathway in LPS-induced lung inflammation.
Title: Specificity of CD200/CD200R pathway in LPS-induced lung inflammation.
CD200R Is Involved in the Anti-inflammatory Effect of Dexmedetomidine in Lipopolysaccharide-Stimulated Microglia.
Title: CD200R Is Involved in the Anti-inflammatory Effect of Dexmedetomidine in Lipopolysaccharide-Stimulated Microglia.
The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke.
Title: The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke.
Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems.
Title: Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems.
Authors found that exposure to a severe acute stressor (inescapable tailshock) induced HMGB1 and reduced CD200R1 expression in limbic brain regions and pharmacological blockade of GC signaling (RU486) mitigated these effects of stress.
Title: Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures.
Using a retinoic acid-induced rat model of spina bifida study demonstrate microglial down-regulation of CD200 expression and up-regulation of CD200R. Findings provide new evidence that microglia activation, including the disruption of the endogenous inhibitory system (CD200-CD200R), may participate in the pathogenesis of spina bifida through late gestation.
Title: CD200-CD200R imbalance correlates with microglia and pro-inflammatory activation in rat spinal cords exposed to amniotic fluid in retinoic acid-induced spina bifida.
CD200R in the rat is mainly expressed on myeloid cells but also on non-myeloid cell subsets, and rat cytomegalovirus e127 can deliver inhibitory signals to immune cells by engaging CD200R.
Title: Cellular distribution of CD200 receptor in rats and its interaction with cytomegalovirus e127 protein.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding involved in heterotypic cell-cell adhesion	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterotypic cell-cell adhesion	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of T cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of macrophage migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuroinflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuroinflammatory response	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell surface glycoprotein CD200 receptor 1

Names: CD200 cell surface glycoprotein receptor; OX102 antigen; OX2 receptor; antigen identified by monoclonal antibody MRC OX-2 receptor; cell surface glycoprotein OX2 receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023953.2 → NP_076443.1 cell surface glycoprotein CD200 receptor 1 precursor

See identical proteins and their annotated locations for NP_076443.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q6PS97, Q9ES58

UniProtKB/TrEMBL

A6IQZ7

Related

ENSRNOP00000002799.3, ENSRNOT00000002799.7

Conserved Domains (3) summary

cd00096
Location:172 → 178

Ig; Ig strand C [structural motif]

cd20985
Location:40 → 147

IgV_CD200R-like; Immunoglobulin Variable domain of cell surface glycoprotein CD200 receptor and similar proteins

cl11960
Location:162 → 217

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

69392943..69427213 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088612.2 → XP_038944540.1 cell surface glycoprotein CD200 receptor 1 isoform X3

Conserved Domains (2) summary

cd00096
Location:5 → 11

Ig; Ig strand A [structural motif]

cl11960
Location:5 → 112

Ig; Immunoglobulin domain
XM_008768743.4 → XP_008766965.1 cell surface glycoprotein CD200 receptor 1 isoform X1

Conserved Domains (1) summary

cl11960
Location:40 → 143

Ig; Immunoglobulin domain
XM_006248347.5 → XP_006248409.1 cell surface glycoprotein CD200 receptor 1 isoform X4

Conserved Domains (1) summary

cl11960
Location:41 → 147

Ig; Immunoglobulin domain
XM_039088611.2 → XP_038944539.1 cell surface glycoprotein CD200 receptor 1 isoform X2

Conserved Domains (3) summary

cd00096
Location:141 → 147

Ig; Ig strand C [structural motif]

cd20985
Location:9 → 116

IgV_CD200R-like; Immunoglobulin Variable domain of cell surface glycoprotein CD200 receptor and similar proteins

cl11960
Location:131 → 186

Ig; Immunoglobulin domain