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    Slc6a15 solute carrier family 6 member 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc6a15provided by RGD
    Official Full Name
    solute carrier family 6 member 15provided by RGD
    Primary source
    RGD:628664
    See related
    EnsemblRapid:ENSRNOG00000027468 AllianceGenome:RGD:628664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ntt73
    Summary
    Predicted to enable branched-chain amino acid:sodium symporter activity; neutral L-amino acid:sodium symporter activity; and proline:sodium symporter activity. Predicted to be involved in L-leucine transport; proline transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human SLC6A15 (solute carrier family 6 member 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 160.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc6a15 in Genome Data Viewer
    Location:
    7q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (40439607..40493788)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (38553055..38607239)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (45328207..45381920)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and IQ motif containing 1 Neighboring gene uncharacterized LOC134479679 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120093576 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neurotransmitter transporter family cDNAs in a rat midbrain library: 'orphan transporters' suggest sizable structural variations. Uhl GR, et al. Brain Res Mol Brain Res, 1992 Dec. PMID 1363329
    2. Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors. Drgonova J, et al. Brain Res, 2007 Dec 5. PMID 17931606, Free PMC Article
    3. Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain. Takanaga H, et al. Biochem Biophys Res Commun, 2005 Nov 25. PMID 16226721
    4. Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport. Zaia KA, et al. J Biol Chem, 2009 Mar 27. PMID 19147495, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables branched-chain amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables branched-chain amino acid:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neutral L-amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proline:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carboxylic acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proline transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent neutral amino acid transporter B(0)AT2
    Names
    orphan sodium- and chloride-dependent neurotransmitter transporter NTT73
    orphan transporter v7-3
    sodium- and chloride-dependent neurotransmitter transporter NTT73
    solute carrier family 6 (neurotransmitter transporter), member 15
    solute carrier family 6 (neutral amino acid transporter), member 15
    transporter v7-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172321.4 → NP_758824.1  sodium-dependent neutral amino acid transporter B(0)AT2

      See identical proteins and their annotated locations for NP_758824.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q08469, Q63838
      UniProtKB/TrEMBL
      A6IGB4
      Conserved Domains (1) summary
      cd11522
      Location:61 → 640
      SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      40439607..40493788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078522.2 → XP_038934450.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

      UniProtKB/Swiss-Prot
      Q08469, Q63838
      UniProtKB/TrEMBL
      A6IGB4
      Related
      ENSRNOP00000032996.4, ENSRNOT00000029208.7
      Conserved Domains (1) summary
      cd11522
      Location:61 → 640
      SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08469.1 GenPept UniProtKB/Swiss-Prot:Q08469

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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