Muc3 mucin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Muc3provided by RGD
Official Full Name: mucin 3provided by RGD
Primary source: RGD:3124
See related: AllianceGenome:RGD:3124
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Muc3a
Summary: Predicted to enable PDZ domain binding activity. Involved in response to Gram-positive bacterium; response to hormone; and response to vitamin A. Located in apical plasma membrane. Used to study colitis. Biomarker of cholangitis; colitis; liver cirrhosis; and otitis media. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 12q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (25139076..25175249)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19527251..19536924)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22535663..22584775)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Muc3 gene was 3-fold higher in the colonic mucosa from high protein rats and 3.5-fold more expressed in the ileal mucosa from high protein rats than in normal protein rats.
Title: High-protein diet differently modifies intestinal goblet cell characteristics and mucosal cytokine expression in ileum and colon.
interaction of the heterodimer was independent of the N-glycans within the rodent Muc3 SEA module.
Title: Role of N-glycosylation of the SEA module of rodent Muc3 in posttranslational processing of its carboxy-terminal domain.
In rats fed the [high molecular weight konjac mannan] diet, ileal Muc2 gene expression was not affected, but that of Muc3 was lower than in those fed the control diet...
Title: Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats.
The present study demonstrates how the conservative cleavage motif LS1KGS2IV1V2 contributes to posttranslational processing through mutagenesis of each residue in the LS(1)KGS2IV1V2 motif.
Title: Contribution of the conservative cleavage motif to posttranslational processing of the carboxyl terminal domain of rodent Muc3.
Identification of a proteolytic site sequence in the C-terminal domain of Mucin3.
Title: Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in response to Gram-positive bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucin 3; uncharacterized protein Muc3

Names: Mucin3; mucin 3, intestinal; mucin 3A, cell surface associated; mucin-12; mucin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.