Scrib scribble planar cell polarity protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scribprovided by RGD
Official Full Name: scribble planar cell polarity proteinprovided by RGD
Primary source: RGD:1565055
See related: EnsemblRapid:ENSRNOG00000032574 AllianceGenome:RGD:1565055
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565055
Summary: Predicted to enable protein kinase binding activity and signaling adaptor activity. Involved in several processes, including astrocyte cell migration; neurotransmitter receptor transport, endosome to postsynaptic membrane; and regulation of postsynaptic neurotransmitter receptor internalization. Located in cell-cell junction. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 78.9), Kidney (RPKM 76.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (109640034..109663354, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (107759343..107782364, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (117105810..117128802, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Scrib1 YxxR motif interacts with AP2 to control NMDAR postendocytic traffic
Title: Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling.
Scribble complexes with HRas and Rac1 and controls neurite growth in NGF-treated PC12 cells.
Title: Scribble controls NGF-mediated neurite outgrowth in PC12 cells.
Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis
Title: The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis.
beta-pix forms a complex with cadherin, beta-catenin, and scribble at synapses and enhances localized actin polymerization in rat hippocampal neurons.
Title: β-Pix modulates actin-mediated recruitment of synaptic vesicles to synapses.
Data show that Rac1 and betaPIX are indirect targets of NS5 acting through the multifunctional polarity protein Scribble to oppose neuronal differentiation.
Title: Rac1 and Scribble are targets for the arrest of neurite outgrowth by TBE virus NS5.
Scribble associates with neuronal nitric oxide synthase adaptor protein (NOS1AP) and is found both presynaptically and postsynaptically.
Title: NOS1AP associates with Scribble and regulates dendritic spine development.
Study concludes that Scrib plays a key role in the establishment of cell polarity during migration, by interacting with betaPIX; Scrib controls localization and activation of the small GTPase Cdc42 and regulates Cdc42-dependent polarization pathways.
Title: Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141209 (e-PCR)
- UniSTS:223205

BE119987 (e-PCR)
- UniSTS:249320

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process involved in morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in astrocyte cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within auditory receptor cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within auditory receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlear nucleus development	ISO Inferred from Sequence Orthology more info
involved_in epithelial structure maintenance	ISO Inferred from Sequence Orthology more info
involved_in establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of apical/basal cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of embryonic epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarized epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-anal tail morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to adherens junction	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle targeting	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport in synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport in synapse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Scrib-APC-beta-catenin complex	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in myelin sheath abaxonal region	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein scribble homolog

Names: scribbled homolog; scribbled planar cell polarity protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191879.3 → NP_001178808.1 protein scribble homolog

See identical proteins and their annotated locations for NP_001178808.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6HS53

Related

ENSRNOP00000111392.1, ENSRNOT00000156470.1

Conserved Domains (7) summary

smart00228
Location:709 → 797

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:12 → 232

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:986 → 1074

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:289 → 329

LRR_4; Leucine Rich repeats (2 copies)

pfam16182
Location:1563 → 1657

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

109640034..109663354 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594968.3 → XP_017450457.2 protein scribble homolog isoform X1

Conserved Domains (6) summary

smart00228
Location:708 → 796

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

PRK14971
Location:1268 → 1436

PRK14971; DNA polymerase III subunit gamma/tau

cd00992
Location:985 → 1073

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam16182
Location:1565 → 1656

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_063263873.1 → XP_063119943.1 protein scribble homolog isoform X11
XM_063263872.1 → XP_063119942.1 protein scribble homolog isoform X10

UniProtKB/TrEMBL

A0A8I6ANK4

Related

ENSRNOP00000095517.1, ENSRNOT00000102170.2
XM_039079543.2 → XP_038935471.1 protein scribble homolog isoform X2

Conserved Domains (6) summary

smart00228
Location:691 → 776

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

PRK14971
Location:1248 → 1416

PRK14971; DNA polymerase III subunit gamma/tau

cd00992
Location:965 → 1053

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam16182
Location:1545 → 1636

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_063263871.1 → XP_063119941.1 protein scribble homolog isoform X9

UniProtKB/TrEMBL

A0A8I6ABB5

Related

ENSRNOP00000090189.1, ENSRNOT00000101717.2
XM_039079545.2 → XP_038935473.1 protein scribble homolog isoform X7

Conserved Domains (5) summary

smart00228
Location:709 → 797

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:986 → 1074

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam16182
Location:1517 → 1608

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_063263870.1 → XP_063119940.1 protein scribble homolog isoform X6
XM_039079544.2 → XP_038935472.1 protein scribble homolog isoform X3

Conserved Domains (6) summary

smart00228
Location:709 → 797

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

PRK14971
Location:1257 → 1416

PRK14971; DNA polymerase III subunit gamma/tau

cd00992
Location:986 → 1074

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam16182
Location:1545 → 1636

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_006241819.5 → XP_006241881.1 protein scribble homolog isoform X8

UniProtKB/TrEMBL

A0A8I6APB3

Related

ENSRNOP00000095752.1, ENSRNOT00000097559.2

Conserved Domains (6) summary

smart00228
Location:709 → 797

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:12 → 232

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:986 → 1074

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:289 → 329

LRR_4; Leucine Rich repeats (2 copies)
XM_008765578.4 → XP_008763800.1 protein scribble homolog isoform X5

See identical proteins and their annotated locations for XP_008763800.1

UniProtKB/TrEMBL

A6HS51

Conserved Domains (7) summary

smart00228
Location:709 → 797

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:12 → 232

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:986 → 1074

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:289 → 329

LRR_4; Leucine Rich repeats (2 copies)

pfam16182
Location:1535 → 1629

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_006241818.5 → XP_006241880.1 protein scribble homolog isoform X4

See identical proteins and their annotated locations for XP_006241880.1

UniProtKB/TrEMBL

A6HS52, D3ZWS0

Related

ENSRNOP00000044022.4, ENSRNOT00000045280.6

Conserved Domains (6) summary

smart00228
Location:709 → 797

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:12 → 232

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:986 → 1074

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:289 → 329

LRR_4; Leucine Rich repeats (2 copies)