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    Spns1 SPNS lysolipid transporter 1, lysophospholipid [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361648, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spns1provided by RGD
    Official Full Name
    SPNS lysolipid transporter 1, lysophospholipidprovided by RGD
    Primary source
    RGD:1305613
    See related
    EnsemblRapid:ENSRNOG00000017621 AllianceGenome:RGD:1305613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305613
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in lysophospholipid transport and phospholipid efflux. Predicted to act upstream of or within regulation of lysosomal lumen pH. Predicted to be located in lysosomal membrane. Predicted to be active in lysosome and membrane. Orthologous to human SPNS1 (SPNS lysolipid transporter 1, lysophospholipid). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 157.0), Brain (RPKM 112.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spns1 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190372663..190380192, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (180942088..180949415, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197771196..197778506, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483833 Neighboring gene linker for activation of T cells Neighboring gene nuclear factor of activated T-cells 2 interacting protein Neighboring gene ribosomal protein L36 like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125152

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysophospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysophospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysophospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid efflux IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid efflux IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lysosomal lumen pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of lysosomal lumen pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein spinster homolog 1
    Names
    RSpin1
    SPNS sphingolipid transporter 1
    sphingolipid transporter 1
    spinster homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039208.2 → NP_001034297.2  protein spinster homolog 1

      See identical proteins and their annotated locations for NP_001034297.2

      Status: VALIDATED

      Source sequence(s)
      BC087072, BU671623, CA339235, CK604160
      UniProtKB/Swiss-Prot
      Q2YDU8
      UniProtKB/TrEMBL
      A0A8I5ZQL7, A6I944
      Related
      ENSRNOP00000024185.4, ENSRNOT00000024185.8
      Conserved Domains (2) summary
      cd06174
      Location:62 → 450
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:65 → 418
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190372663..190380192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267693.1 → XP_063123763.1  protein spinster homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQL7

    2. XM_063267690.1 → XP_063123760.1  protein spinster homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQL7, A0A8I6ADI2
      Related
      ENSRNOP00000089943.1, ENSRNOT00000119722.2

    3. XM_017589399.3 → XP_017444888.1  protein spinster homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YDU8
      UniProtKB/TrEMBL
      A0A8I5ZQL7, A6I944
      Conserved Domains (2) summary
      cd06174
      Location:62 → 450
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:65 → 418
      MFS_1; Major Facilitator Superfamily

    4. XM_063267695.1 → XP_063123765.1  protein spinster homolog 1 isoform X4

      UniProtKB/TrEMBL
      A6I945

    5. XM_063267698.1 → XP_063123768.1  protein spinster homolog 1 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2YDU8.2 GenPept UniProtKB/Swiss-Prot:Q2YDU8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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