Mn1 MN1 proto-oncogene, transcriptional regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mn1provided by RGD
Official Full Name: MN1 proto-oncogene, transcriptional regulatorprovided by RGD
Primary source: RGD:1565571
See related: EnsemblRapid:ENSRNOG00000027489 AllianceGenome:RGD:1565571
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565571
Summary: Predicted to be involved in negative regulation of osteoblast proliferation; positive regulation of vitamin D receptor signaling pathway; and regulation of cell cycle G1/S phase transition. Predicted to act upstream of or within intramembranous ossification. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in familial meningioma; meningioma; and myeloid leukemia. Orthologous to human MN1 (MN1 proto-oncogene, transcriptional regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 78.3), Heart (RPKM 59.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (50841632..50880795, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (45181794..45220959, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (51214192..51250230, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within intramembranous ossification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vitamin D receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcriptional activator MN1

Names: meningioma 1; probable tumor suppressor protein MN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.