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    Rmnd1 required for meiotic nuclear division 1 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rmnd1provided by RGD
    Official Full Name
    required for meiotic nuclear division 1 homologprovided by RGD
    Primary source
    RGD:1309546
    See related
    EnsemblRapid:ENSRNOG00000019501 AllianceGenome:RGD:1309546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Iag-1; RGD1309546
    Summary
    Predicted to be involved in positive regulation of mitochondrial translation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 11. Orthologous to human RMND1 (required for meiotic nuclear division 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 165.7), Adrenal (RPKM 160.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rmnd1 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43265207..43299748, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (40859829..40894376, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (40948843..40982669, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 12 Neighboring gene zinc finger and BTB domain containing 2 Neighboring gene zinc finger and BTB domain containing 2 like Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene uncharacterized LOC134482620

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Implantation-associated gene-1 (Iag-1): a novel gene involved in the early process of embryonic implantation in rat. Xia HF, et al. Hum Reprod, 2008 Jul. PMID 18296448
    2. RMND1 deficiency associated with neonatal lactic acidosis, infantile onset renal failure, deafness, and multiorgan involvement. Janer A, et al. Eur J Hum Genet, 2015 Oct. PMID 25604853, Free PMC Article
    3. Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects. Li D, et al. Sci Total Environ, 2023 Apr 15. PMID 36690096
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
      Title: Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
    2. Overexpression of Iag-1 can inhibit endometrial stromal cell proliferation and induce endometrial stroma cells apoptosis, and p53 and Bax may play an important role in the process of Iag-1-induced apoptosis.
      Title: Implantation-associated gene-1 (Iag-1): a novel gene involved in the early process of embryonic implantation in rat.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    required for meiotic nuclear division protein 1 homolog
    Names
    implantation-associated gene-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040128.2 → NP_001035217.2  required for meiotic nuclear division protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KIL2, E9PU34, Q1W176
      Related
      ENSRNOP00000057484.3, ENSRNOT00000060757.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      43265207..43299748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103392.1 → XP_038959320.1  required for meiotic nuclear division protein 1 homolog isoform X1

      UniProtKB/TrEMBL
      A6KIL2, E9PU34, Q1W176
      Conserved Domains (1) summary
      pfam02582
      Location:227 → 404
      DUF155; Uncharacterized ACR, YagE family COG1723

    2. XM_017588871.3 → XP_017444360.1  required for meiotic nuclear division protein 1 homolog isoform X1

      UniProtKB/TrEMBL
      A6KIL2, E9PU34, Q1W176
      Conserved Domains (1) summary
      pfam02582
      Location:227 → 404
      DUF155; Uncharacterized ACR, YagE family COG1723

    3. XM_039103400.2 → XP_038959328.1  required for meiotic nuclear division protein 1 homolog isoform X1

      UniProtKB/TrEMBL
      A6KIL2, E9PU34, Q1W176
      Conserved Domains (1) summary
      pfam02582
      Location:227 → 404
      DUF155; Uncharacterized ACR, YagE family COG1723

    4. XM_039103410.2 → XP_038959338.1  required for meiotic nuclear division protein 1 homolog isoform X1

      UniProtKB/TrEMBL
      A6KIL2, E9PU34, Q1W176
      Conserved Domains (1) summary
      pfam02582
      Location:227 → 404
      DUF155; Uncharacterized ACR, YagE family COG1723

    5. XM_039103441.2 → XP_038959369.1  required for meiotic nuclear division protein 1 homolog isoform X4

      Conserved Domains (1) summary
      pfam02582
      Location:6 → 160
      DUF155; Uncharacterized ACR, YagE family COG1723

    6. XM_039103420.1 → XP_038959348.1  required for meiotic nuclear division protein 1 homolog isoform X2

      Conserved Domains (1) summary
      pfam02582
      Location:227 → 313
      DUF155; Uncharacterized ACR, YagE family COG1723

    7. XM_039103431.2 → XP_038959359.1  required for meiotic nuclear division protein 1 homolog isoform X3

      Conserved Domains (1) summary
      cl00751
      Location:117 → 239
      DUF155; Uncharacterized ACR, YagE family COG1723

    RNA

    1. XR_005500480.1 RNA Sequence

    2. XR_005500484.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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