Anxa4 annexin A4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Anxa4provided by RGD
Official Full Name: annexin A4provided by RGD
Primary source: RGD:621171
See related: EnsemblRapid:ENSRNOG00000018159 AllianceGenome:RGD:621171
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Anx4
Summary: Predicted to enable several functions, including NF-kappaB binding activity; calcium-dependent protein binding activity; and phospholipid binding activity. Predicted to be involved in epithelial cell differentiation and regulation of gene expression. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in cell surface; nuclear membrane; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Orthologous to human ANXA4 (annexin A4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 615.3), Kidney (RPKM 366.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (120741750..120798534, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (119184378..119241183, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (118538775..118595591, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANXA4 overexpression in placenta alleviated pre-eclampsia in an animal model.
Title: ANXA4 promotes trophoblast invasion via the PI3K/Akt/eNOS pathway in preeclampsia.
role of calcium-binding sites in calcium-dependent membrane association of annexin A4
Title: Role of calcium-binding sites in calcium-dependent membrane association of annexin A4.
In this study, we resolved two crystal structures of the Na(+)-bound form of annexin A4.
Title: Crystal structures of sodium-bound annexin A4.
the rabphilin C2B domain interacts directly with the N-terminus of annexin A4 and mediates the co-complexing of these two proteins which co-localise at the plasma membrane annexin; A4 may play a role in synaptic exocytosis.
Title: Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134069 (e-PCR)
- UniSTS:217351

AU048940 (e-PCR)
- UniSTS:145390

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: annexin A4

Names: 36 kDa zymogen granule membrane-associated protein; ZAP 36/annexin IV; ZAP36; annexin IV; annexin-4; lipocortin IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024155.3 → NP_077069.3 annexin A4

See identical proteins and their annotated locations for NP_077069.3

Status: PROVISIONAL

Source sequence(s)

BC085688

UniProtKB/Swiss-Prot

P55260

UniProtKB/TrEMBL

A6IAZ2, F7ERI2, Q5U362

Related

ENSRNOP00000024436.5, ENSRNOT00000024436.9

Conserved Domains (1) summary

pfam00191
Location:249 → 314

Annexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

120741750..120798534 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236841.5 → XP_006236903.1 annexin A4 isoform X1

See identical proteins and their annotated locations for XP_006236903.1

UniProtKB/Swiss-Prot

P55260

UniProtKB/TrEMBL

A6IAZ2, F7ERI2, Q5U362

Conserved Domains (1) summary

pfam00191
Location:249 → 314

Annexin
XM_063286727.1 → XP_063142797.1 annexin A4 isoform X1

UniProtKB/Swiss-Prot

P55260

UniProtKB/TrEMBL

A6IAZ2, F7ERI2, Q5U362
XM_039108397.2 → XP_038964325.1 annexin A4 isoform X1

UniProtKB/Swiss-Prot

P55260

UniProtKB/TrEMBL

A6IAZ2, F7ERI2, Q5U362

Conserved Domains (1) summary

pfam00191
Location:249 → 314

Annexin
XM_039108398.2 → XP_038964326.1 annexin A4 isoform X1

UniProtKB/Swiss-Prot

P55260

UniProtKB/TrEMBL

A6IAZ2, F7ERI2, Q5U362

Conserved Domains (1) summary

pfam00191
Location:249 → 314

Annexin
XM_039108396.2 → XP_038964324.1 annexin A4 isoform X1

UniProtKB/Swiss-Prot

P55260

UniProtKB/TrEMBL

A6IAZ2, F7ERI2, Q5U362

Conserved Domains (1) summary

pfam00191
Location:249 → 314

Annexin