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    Lrrc10 leucine-rich repeat-containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314848, updated on 9-Dec-2024

    Summary

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    Symbol
    Lrrc10provided by RGD
    Full Name
    leucine-rich repeat-containing 10provided by RGD
    Primary source
    RGD:1307358
    See related
    EnsemblRapid:ENSRNOG00000005555 AllianceGenome:RGD:1307358
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity and alpha-actinin binding activity. Predicted to be involved in cardiac muscle cell development. Predicted to be located in mitochondrion; myofibril; and nucleus. Predicted to be active in cytoskeleton and sarcomere. Orthologous to human LRRC10 (leucine rich repeat containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc10 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54572935..54574332)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52686972..52688369)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (60087361..60088758)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene RNA 2',3'-cyclic phosphate and 5'-OH ligase, pseudogene 1 Neighboring gene uncharacterized LOC120093599 Neighboring gene chaperonin containing TCP1 subunit 2 Neighboring gene fibroblast growth factor receptor substrate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein. Nakane T, et al. Biochem Biophys Res Commun, 2004 Feb 20. PMID 14751244
    2. Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein. Adameyko II, et al. Dev Dyn, 2005 Jun. PMID 15830381
    3. Serdin1/Lrrc10 is dispensable for mouse development. Manuylov NL, et al. Genesis, 2008 Sep. PMID 18781631
    4. Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. Brody MJ, et al. PLoS One, 2012. PMID 23236519, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sarcomere IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 10
    Names
    leucine-rich repeat-containing protein 10-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108096.1 → NP_001101566.1  leucine-rich repeat-containing protein 10

      See identical proteins and their annotated locations for NP_001101566.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/TrEMBL
      A6IGR3, D4AAU8
      Related
      ENSRNOP00000007338.2, ENSRNOT00000007338.5
      Conserved Domains (3) summary
      cd00116
      Location:88 → 200
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:32 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:52 → 110
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      54572935..54574332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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