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    Meis2 Meis homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Meis2provided by RGD
    Official Full Name
    Meis homeobox 2provided by RGD
    Primary source
    RGD:1305198
    See related
    EnsemblRapid:ENSRNOG00000004730 AllianceGenome:RGD:1305198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pancreas development; response to growth factor; and response to mechanical stimulus. Predicted to be active in nucleus. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in cleft palate; cleft palate, cardiac defects, and intellectual disabillity; learning disability; open-angle glaucoma; and orofacial cleft. Orthologous to human MEIS2 (Meis homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 250.9), Uterus (RPKM 119.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Meis2 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (123197066..123399002, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (102742904..102944833, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (107560172..107762732, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553090 Neighboring gene CDAN1 interacting nuclease 1 Neighboring gene uncharacterized LOC134486425 Neighboring gene uncharacterized LOC103691864 Neighboring gene uncharacterized LOC102555456

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. Gustafsson E, et al. Eur J Neurosci, 2003 Jun. PMID 12823474
    2. Expression of stem cell markers and transcription factors during the remodeling of the rat pancreas after duct ligation. Peters K, et al. Virchows Arch, 2005 Jan. PMID 15660282
    3. Heterozygous loss-of-function variants of MEIS2 cause a triad of palatal defects, congenital heart defects, and intellectual disability. Verheije R, et al. Eur J Hum Genet, 2019 Feb. PMID 30291340, Free PMC Article
    4. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. Shiga Y, et al. Hum Mol Genet, 2018 Apr 15. PMID 29452408, Free PMC Article
    5. Meis2 represses the osteoblastic transdifferentiation of aortic valve interstitial cells through the Notch1/Twist1 pathway. Sun C, et al. Biochem Biophys Res Commun, 2019 Feb 5. PMID 30594396

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pancreas development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of cardiac muscle myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to growth factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Meis2
    Names
    Meis1, myeloid ecotropic viral integration site 1 homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415696.1 → NP_001402625.1  homeobox protein Meis2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JT27

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      123197066..123399002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234746.5 → XP_006234808.1  homeobox protein Meis2 isoform X2

      UniProtKB/TrEMBL
      A6HP86
      Conserved Domains (2) summary
      pfam05920
      Location:313 → 352
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129 → 212
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. XM_039104936.2 → XP_038960864.1  homeobox protein Meis2 isoform X1

      UniProtKB/TrEMBL
      A6HP86
      Conserved Domains (3) summary
      pfam05920
      Location:313 → 352
      Homeobox_KN; Homeobox KN domain
      pfam09770
      Location:354 → 482
      PAT1; Topoisomerase II-associated protein PAT1
      pfam16493
      Location:129 → 213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. XM_006234749.5 → XP_006234811.1  homeobox protein Meis2 isoform X5

      UniProtKB/TrEMBL
      A6HP86
      Conserved Domains (2) summary
      pfam05920
      Location:294 → 333
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110 → 193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    4. XM_006234747.5 → XP_006234809.1  homeobox protein Meis2 isoform X3

      UniProtKB/TrEMBL
      A6HP86
      Related
      ENSRNOP00000047254.6, ENSRNOT00000051638.6
      Conserved Domains (2) summary
      pfam05920
      Location:294 → 333
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110 → 193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    5. XM_039104937.2 → XP_038960865.1  homeobox protein Meis2 isoform X6

      UniProtKB/TrEMBL
      A6HP86, D4A2T5
      Conserved Domains (2) summary
      pfam05920
      Location:293 → 332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109 → 193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    6. XM_006234748.5 → XP_006234810.1  homeobox protein Meis2 isoform X4

      UniProtKB/TrEMBL
      A6HP86
      Conserved Domains (2) summary
      pfam05920
      Location:293 → 332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109 → 192
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    7. XM_006234751.5 → XP_006234813.1  homeobox protein Meis2 isoform X8

      See identical proteins and their annotated locations for XP_006234813.1

      UniProtKB/TrEMBL
      A0A0G2JT27
      Conserved Domains (2) summary
      pfam05920
      Location:313 → 352
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129 → 213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    8. XM_006234750.5 → XP_006234812.1  homeobox protein Meis2 isoform X7

      See identical proteins and their annotated locations for XP_006234812.1

      UniProtKB/TrEMBL
      A0A0G2JT27
      Conserved Domains (2) summary
      pfam05920
      Location:313 → 352
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129 → 213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    9. XM_006234752.5 → XP_006234814.1  homeobox protein Meis2 isoform X9

      See identical proteins and their annotated locations for XP_006234814.1

      UniProtKB/TrEMBL
      A0A0G2JT27
      Related
      ENSRNOP00000093627.2, ENSRNOT00000098248.2
      Conserved Domains (2) summary
      pfam05920
      Location:294 → 333
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110 → 194
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    10. XM_006234755.5 → XP_006234817.1  homeobox protein Meis2 isoform X11

      See identical proteins and their annotated locations for XP_006234817.1

      UniProtKB/TrEMBL
      A0A0G2JT27
      Conserved Domains (2) summary
      pfam05920
      Location:293 → 332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109 → 193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    11. XM_006234753.5 → XP_006234815.1  homeobox protein Meis2 isoform X10

      See identical proteins and their annotated locations for XP_006234815.1

      UniProtKB/TrEMBL
      A0A0G2JT27, A0A8I6AHY1
      Related
      ENSRNOP00000068546.3, ENSRNOT00000077091.3
      Conserved Domains (2) summary
      pfam05920
      Location:293 → 332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109 → 193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107758.2: Suppressed sequence

      Description
      NM_001107758.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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