Gnl3l G protein nucleolar 3 like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnl3lprovided by RGD
Official Full Name: G protein nucleolar 3 likeprovided by RGD
Primary source: RGD:1600217
See related: EnsemblRapid:ENSRNOG00000002509 AllianceGenome:RGD:1600217
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity. Predicted to be involved in several processes, including negative regulation of protein modification by small protein conjugation or removal; negative regulation of telomere maintenance via telomerase; and positive regulation of protein localization to chromosome, telomeric region. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in nucleolus. Orthologous to human GNL3L (G protein nucleolar 3 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 304.1), Heart (RPKM 290.3) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: Xq12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (23404324..23437501, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (19961277..19994454, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (20037558..20070505, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: guanine nucleotide-binding protein-like 3-like protein

Names: guanine nucleotide binding protein-like 3 (nucleolar)-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081958.1 → NP_001075427.1 guanine nucleotide-binding protein-like 3-like protein

Status: PROVISIONAL

Source sequence(s)

CA505625, CA512184, CB544748, CB783942, CB801341

UniProtKB/TrEMBL

D3ZMZ9

Related

ENSRNOP00000003397.9, ENSRNOT00000003397.10

Conserved Domains (2) summary

cd04178
Location:129 → 301

Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases

TIGR03596
Location:119 → 391

GTPase_YlqF; ribosome biogenesis GTP-binding protein YlqF