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    Khsrp KH-type splicing regulatory protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171137, updated on 9-Dec-2024

    Summary

    Official Symbol
    Khsrpprovided by RGD
    Official Full Name
    KH-type splicing regulatory proteinprovided by RGD
    Primary source
    RGD:621828
    See related
    EnsemblRapid:ENSRNOG00000047628 AllianceGenome:RGD:621828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Marta1
    Summary
    Enables mRNA 3'-UTR binding activity. Predicted to be involved in several processes, including negative regulation of low-density lipoprotein particle clearance; negative regulation of nitric oxide biosynthetic process; and regulation of RNA metabolic process. Predicted to act upstream of or within mRNA catabolic process and regulation of miRNA metabolic process. Located in dendrite and neuronal cell body. Orthologous to human KHSRP (KH-type splicing regulatory protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 83.9), Thymus (RPKM 69.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Khsrp in Genome Data Viewer
    Location:
    9q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1949557..1959400, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1862555..1872403, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10013795..10023670)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene alkB homolog 7 Neighboring gene persephin Neighboring gene general transcription factor IIF subunit 1 Neighboring gene adenylate kinase isoenzyme 5 Neighboring gene solute carrier family 25, member 41 Neighboring gene solute carrier family 25 member 23

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables RNA binding  
    enables mRNA 3'-UTR AU-rich region binding  
    enables mRNA 3'-UTR AU-rich region binding  
    enables mRNA 3'-UTR binding PubMed 
    enables mRNA binding  
    enables mRNA binding  
    enables mRNA binding  
    enables protein binding PubMed 
    enables protein folding chaperone  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization  
    involved_in 3'-UTR-mediated mRNA destabilization  
    involved_in RNA splicing  
    involved_in cellular response to cytokine stimulus  
    involved_in cellular response to cytokine stimulus  
    involved_in mRNA catabolic process  
    acts_upstream_of_or_within mRNA catabolic process  
    involved_in mRNA processing  
    involved_in mRNA transport  
    involved_in miRNA metabolic process  
    involved_in miRNA metabolic process  
    involved_in negative regulation of low-density lipoprotein particle clearance  
    involved_in negative regulation of nitric oxide biosynthetic process  
    involved_in negative regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of mRNA catabolic process  
    involved_in positive regulation of mRNA catabolic process  
    involved_in protein folding  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of mRNA stability  
    involved_in regulation of mRNA stability  
    involved_in regulation of miRNA metabolic process  
    acts_upstream_of_or_within regulation of miRNA metabolic process  
    involved_in regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule  
    located_in dendrite PubMed 
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    far upstream element-binding protein 2
    Names
    FUSE-binding protein 2
    KSRP
    MAP2 RNA trans-acting protein 1
    MAP2 RNA trans-acting protein MARTA1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395096.1NP_001382025.1  far upstream element-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q99PF5
      UniProtKB/TrEMBL
      A0A0G2K2B3
      Related
      ENSRNOP00000072174.2, ENSRNOT00000077653.3
      Conserved Domains (5) summary
      pfam09005
      Location:672686
      DUF1897; Domain of unknown function (DUF1897)
      cd22479
      Location:146216
      KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22482
      Location:234306
      KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22485
      Location:324391
      KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22488
      Location:427495
      KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1949557..1959400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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