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    Ufm1 ubiquitin-fold modifier 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365797, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ufm1provided by RGD
    Official Full Name
    ubiquitin-fold modifier 1provided by RGD
    Primary source
    RGD:1304890
    See related
    EnsemblRapid:ENSRNOG00000038176 AllianceGenome:RGD:1304890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304890
    Summary
    Involved in negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 14. Orthologous to human UFM1 (ubiquitin fold modifier 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 182.1), Liver (RPKM 142.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ufm1 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (140119722..140127866, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (137969476..137977620, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (143096268..143104412, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 15 open reading frame 40, pseudogene 1 Neighboring gene peroxiredoxin 1, pseudogene 8 Neighboring gene uncharacterized LOC102549721 Neighboring gene transient receptor potential cation channel, subfamily C, member 4 Neighboring gene uncharacterized LOC134485914

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC109501

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in brain development  
    involved_in brain development  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of protein import into nucleus  
    involved_in protein K69-linked ufmylation  
    involved_in protein K69-linked ufmylation  
    involved_in protein ufmylation  
    involved_in protein ufmylation  
    NOT involved_in regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in regulation of intracellular estrogen receptor signaling pathway  
    involved_in regulation of intracellular estrogen receptor signaling pathway  
    involved_in response to endoplasmic reticulum stress  
    acts_upstream_of_or_within response to endoplasmic reticulum stress  
    involved_in response to endoplasmic reticulum stress  
    involved_in response to endoplasmic reticulum stress  
    involved_in reticulophagy  
    involved_in reticulophagy  
    involved_in reticulophagy  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in endoplasmic reticulum  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126080.2NP_001119552.1  ubiquitin-fold modifier 1

      See identical proteins and their annotated locations for NP_001119552.1

      Status: VALIDATED

      Source sequence(s)
      BP500691, BQ780192, CB787557, CV112030, FM094134, FM099369
      UniProtKB/Swiss-Prot
      Q5BJP3
      Related
      ENSRNOP00000102397.1, ENSRNOT00000058116.5
      Conserved Domains (1) summary
      cd01766
      Location:478
      Ubl_UFM1; ubiquitin-like (Ubl) domain found in ubiquitin fold modifier 1 (UFM1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      140119722..140127866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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