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    Micu3 mitochondrial calcium uptake family, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364601, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Micu3provided by RGD
    Official Full Name
    mitochondrial calcium uptake family, member 3provided by RGD
    Primary source
    RGD:1563411
    See related
    EnsemblRapid:ENSRNOG00000012767 AllianceGenome:RGD:1563411
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Efha2
    Summary
    Enables calcium ion sensor activity. Involved in calcium import into the mitochondrion. Acts upstream of with a positive effect on positive regulation of neurotransmitter secretion. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of uniplex complex. Predicted to be active in mitochondrion. Orthologous to human MICU3 (mitochondrial calcium uptake family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 191.6), Kidney (RPKM 38.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Micu3 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (58624702..58714302, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51919859..52010705, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (55043051..55133080, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene zinc finger DHHC-type palmitoyltransferase 2 Neighboring gene fibroblast growth factor 20 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats. Wang J, et al. Exp Neurol, 2023 Mar. PMID 36549422
    2. Molecular Tuning of the Axonal Mitochondrial Ca(2+) Uniporter Ensures Metabolic Flexibility of Neurotransmission. Ashrafi G, et al. Neuron, 2020 Feb 19. PMID 31862210, Free PMC Article
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats.
      Title: Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium import into the mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium import into the mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_positive_effect positive regulation of neurotransmitter secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcium uptake protein 3, mitochondrial
    Names
    EF hand domain family, member A2
    EF-hand domain-containing family member A2
    mitochondrial uptake family, member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191892.1 → NP_001178821.1  calcium uptake protein 3, mitochondrial

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0AAK3FFS0
      Related
      ENSRNOP00000017025.6, ENSRNOT00000017025.9
      Conserved Domains (3) summary
      pfam05763
      Location:325 → 413
      DUF835; Protein of unknown function (DUF835)
      pfam13499
      Location:421 → 468
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:418 → 471
      EF-hand_8; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      58624702..58714302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094721.2 → XP_038950649.1  calcium uptake protein 3, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0AAK3H8H3
      Related
      ENSRNOP00000082387.1, ENSRNOT00000102161.2
      Conserved Domains (1) summary
      cd16175
      Location:229 → 459
      EFh_MICU3; EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins

    2. XM_008771293.4 → XP_008769515.1  calcium uptake protein 3, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0AAK3HSM7
      Related
      ENSRNOP00000088716.1, ENSRNOT00000099337.2
      Conserved Domains (2) summary
      PTZ00183
      Location:231 → 346
      PTZ00183; centrin; Provisional
      pfam13833
      Location:429 → 482
      EF-hand_8; EF-hand domain pair

    3. XM_006253200.5 → XP_006253262.1  calcium uptake protein 3, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      A0A8I5ZTV9, A0A8I6A2H6, A0A8I6AA12, D3ZG95
      Related
      ENSRNOP00000087041.1, ENSRNOT00000098345.2
      Conserved Domains (1) summary
      pfam13833
      Location:442 → 495
      EF-hand_8; EF-hand domain pair

    4. XM_063275597.1 → XP_063131667.1  calcium uptake protein 3, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A6JPW1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A8I6A2H6.1 GenPept UniProtKB/Swiss-Prot:A0A8I6A2H6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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