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    Mfap2 microfibril associated protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313662, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mfap2provided by RGD
    Official Full Name
    microfibril associated protein 2provided by RGD
    Primary source
    RGD:1306031
    See related
    EnsemblRapid:ENSRNOG00000008257 AllianceGenome:RGD:1306031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fibrinogen binding activity and fibronectin binding activity. Predicted to be involved in embryonic eye morphogenesis; positive regulation of cold-induced thermogenesis; and post-embryonic eye morphogenesis. Predicted to act upstream of or within platelet formation. Predicted to be located in extracellular region. Predicted to be active in microfibril. Orthologous to human MFAP2 (microfibril associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 80.2), Lung (RPKM 71.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfap2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (158595121..158603283)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153312068..153320266)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159534202..159539750)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene peptidyl arginine deiminase 2 Neighboring gene succinate dehydrogenase complex iron sulfur subunit B Neighboring gene ATPase cation transporting 13A2 Neighboring gene uncharacterized LOC120103023 Neighboring gene ciliary rootlet coiled-coil, rootletin Neighboring gene NECAP endocytosis associated 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study. Zheng Q, et al. Clin Cosmet Investig Dermatol, 2013. PMID 24353434, Free PMC Article
    2. The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-β. Craft CS, et al. Diabetes, 2014 Jun. PMID 24458361, Free PMC Article
    3. Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. Werneck CC, et al. Blood, 2008 Apr 15. PMID 18281502, Free PMC Article
    4. Human eye development is characterized by coordinated expression of fibrillin isoforms. Hubmacher D, et al. Invest Ophthalmol Vis Sci, 2014 Nov 18. PMID 25406291, Free PMC Article
    5. Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation. Collin GB, et al. Hum Mol Genet, 2015 Dec 15. PMID 26405179, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fibrinogen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic eye morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within platelet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in post-embryonic eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microfibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microfibrillar-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107989.2 → NP_001101459.2  microfibrillar-associated protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6ITQ8, D3Z952
      Related
      ENSRNOP00000010993.5, ENSRNOT00000010993.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      158595121..158603283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110070.2 → XP_038965998.1  microfibrillar-associated protein 2 isoform X1

      Conserved Domains (1) summary
      pfam05507
      Location:135 → 216
      MAGP; Microfibril-associated glycoprotein (MAGP)
    Nucleotide Protein Strain
    Heading Accession and Version

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