Fcgr1a Fc gamma receptor 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fcgr1aprovided by RGD
Official Full Name: Fc gamma receptor 1Aprovided by RGD
Primary source: RGD:1309912
See related: EnsemblRapid:ENSRNOG00000021199 AllianceGenome:RGD:1309912
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fcgr1; Fcgr1b; FcgammaRI
Summary: Enables leukotriene receptor binding activity. Involved in several processes, including positive regulation of phagocytosis, engulfment; response to aldosterone; and response to estradiol. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of retinal degeneration. Orthologous to several human genes including FCGR1A (Fc gamma receptor Ia). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 177.3), Lung (RPKM 93.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (186539941..186548941, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (183851075..183860077, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (198430536..198439453, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fcgamma Receptor I-Coupled Signaling in Peripheral Nociceptors Mediates Joint Pain in a Rat Model of Rheumatoid Arthritis.
Title: Fcγ Receptor I-Coupled Signaling in Peripheral Nociceptors Mediates Joint Pain in a Rat Model of Rheumatoid Arthritis.
FcgammaRI is a critical player for peripheral nerve injury-induced neuropathic pain.
Title: The high-affinity IgG receptor FcγRI modulates peripheral nerve injury-induced neuropathic pain in rats.
Expression of TNF-alpha and IL-10 in microglia was elevated to protective levels by neuron-derived IgG at a physiologic level via the FcgammaR I and TLR4 pathways.
Title: Neuron-derived IgG protects dopaminergic neurons from insult by 6-OHDA and activates microglia through the FcγR I and TLR4 pathways.
FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions.
Title: FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions.
After transient BBB opening, FcgammaRI-mediated antiinflammatory processes were activated, whereas TLR4-mediated proinflammatory activities were inhibited in microglia and astrocytes.
Title: Alterations of Fc gamma receptor I and Toll-like receptor 4 mediate the antiinflammatory actions of microglia and astrocytes after adrenaline-induced blood-brain barrier opening in rats.
A positive correlation between CD64 and fibroblast growth factor characterizes the macrophage-fibroblast interactions, the key point in the formation of tubulo-interstitial fibrosis.
Title: Role of CD64, P53 and P21 proteins in the pathogenesis of the tubulo-interstitial syndrome in Masugi chronic nephritis.
IgG transport across alveolar epithelium takes place via regulable FcRn-mediated transcytosis, which may play an important role in alveolar homeostasis in health and disease.
Title: Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers.

Submit: New GeneRIF Correction

General gene information

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Markers

D3Nds11 (e-PCR), detects polymorphism
- UniSTS:142401

D3Nds11 (e-PCR), detects polymorphism
- UniSTS:142402

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgG binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgG binding	ISO Inferred from Sequence Orthology more info
enables IgG receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables IgG receptor activity	ISO Inferred from Sequence Orthology more info
enables high-affinity IgG receptor activity	ISO Inferred from Sequence Orthology more info
enables leukotriene receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antibody-dependent cellular cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antibody-dependent cellular cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in antibody-dependent cellular cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation of exogenous antigen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, recognition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of type III hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in response to aldosterone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to epinephrine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: high affinity immunoglobulin gamma Fc receptor I

Names: Fc fragment of IgG high affinity Ib receptor; Fc fragment of IgG receptor Ia; Fc fragment of IgG, high affinity Ia, receptor (CD64); Fc fragment of IgG, high affinity Ib, receptor for (CD64); Fc gamma receptor Ia; Fc receptor, IgG, high affinity I; high affinity IgG Fc receptor, subunit beta; high-affinity immunoglobulin gamma Fc receptor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100836.1 → NP_001094306.1 high affinity immunoglobulin gamma Fc receptor I precursor

See identical proteins and their annotated locations for NP_001094306.1

Status: PROVISIONAL

Source sequence(s)

AA859169, CF113031, CO555980

UniProtKB/TrEMBL

A0A0B4J2J0, A6K367

Related

ENSRNOP00000028780.4, ENSRNOT00000028780.6

Conserved Domains (3) summary

smart00410
Location:115 → 184

IG_like; Immunoglobulin like

pfam00047
Location:201 → 266

ig; Immunoglobulin domain

cl11960
Location:104 → 184

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

186539941..186548941 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102048.2 → XP_038957976.1 high affinity immunoglobulin gamma Fc receptor I isoform X1

Conserved Domains (3) summary

pfam00047
Location:111 → 176

ig; Immunoglobulin domain

cd00096
Location:14 → 18

Ig; Ig strand A [structural motif]

cl11960
Location:14 → 94

Ig; Immunoglobulin domain