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    Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnajb2provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B2provided by RGD
    Primary source
    RGD:1591035
    See related
    EnsemblRapid:ENSRNOG00000019506 AllianceGenome:RGD:1591035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including Hsp70 protein binding activity; enzyme binding activity; and modification-dependent protein binding activity. Predicted to be involved in several processes, including proteasomal protein catabolic process; protein folding; and regulation of protein metabolic process. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; nuclear membrane; and perinuclear region of cytoplasm. Predicted to be part of proteasome complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 5. Orthologous to human DNAJB2 (DnaJ heat shock protein family (Hsp40) member B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 177.1), Brain (RPKM 160.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajb2 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84179702..84187942)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76731060..76739278)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82436453..82444669)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 16 Neighboring gene uncharacterized LOC102554903 Neighboring gene tubulin, alpha 4A Neighboring gene uncharacterized LOC120094712 Neighboring gene protein tyrosine phosphatase, receptor type, N Neighboring gene regulated endocrine-specific protein 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b. Cheetham ME, et al. Eur J Biochem, 1994 Nov 15. PMID 7957263
    2. The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation. Gao XC, et al. J Biol Chem, 2012 Feb 17. PMID 22219199, Free PMC Article
    3. The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation. Chapple JP, et al. J Biol Chem, 2003 May 23. PMID 12754272
    4. Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Novoselov SS, et al. PLoS One, 2013. PMID 24023695, Free PMC Article
    5. Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. Rose JM, et al. Hum Mol Genet, 2011 Jan 1. PMID 20889486, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
      Title: Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 2
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109541.2 → NP_001103011.1  dnaJ homolog subfamily B member 2 isoform 3

      See identical proteins and their annotated locations for NP_001103011.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JW05, A6JW06, D4ABC2
      Related
      ENSRNOP00000026467.2, ENSRNOT00000026467.6
      Conserved Domains (2) summary
      COG0484
      Location:3 → 92
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:3 → 58
      DnaJ; DnaJ domain

    2. NM_001399115.1 → NP_001386044.1  dnaJ homolog subfamily B member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6A5U2, A6JW06
      Conserved Domains (1) summary
      COG0484
      Location:3 → 110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    3. NM_001399116.1 → NP_001386045.1  dnaJ homolog subfamily B member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6A5U2, A6JW06
      Conserved Domains (1) summary
      COG0484
      Location:3 → 110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    4. NM_001399117.1 → NP_001386046.1  dnaJ homolog subfamily B member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JW06, B2RYA8
      Conserved Domains (1) summary
      COG0484
      Location:3 → 110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    5. NM_001399118.1 → NP_001386047.1  dnaJ homolog subfamily B member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JW06, B2RYA8
      Conserved Domains (1) summary
      COG0484
      Location:3 → 110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      84179702..84187942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245280.2 → XP_006245342.1  dnaJ homolog subfamily B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3U5, A6JW06
      Conserved Domains (4) summary
      COG0484
      Location:3 → 110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:3 → 66
      DnaJ; DnaJ domain
      pfam02809
      Location:250 → 266
      UIM; Ubiquitin interaction motif
      pfam10254
      Location:260 → 307
      Pacs-1; PACS-1 cytosolic sorting protein

    2. XM_006245281.5 → XP_006245343.1  dnaJ homolog subfamily B member 2 isoform X3

      UniProtKB/TrEMBL
      A6JW06
      Conserved Domains (2) summary
      COG0484
      Location:3 → 92
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:3 → 58
      DnaJ; DnaJ domain

    3. XM_063267756.1 → XP_063123826.1  dnaJ homolog subfamily B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3U5, A6JW06
      Related
      ENSRNOP00000074369.2, ENSRNOT00000081958.3

    4. XM_039084218.1 → XP_038940146.1  dnaJ homolog subfamily B member 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZJ88, A6JW06
      Related
      ENSRNOP00000076642.1, ENSRNOT00000098165.2
      Conserved Domains (1) summary
      COG0484
      Location:3 → 110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    5. XM_006245279.5 → XP_006245341.1  dnaJ homolog subfamily B member 2 isoform X1

      See identical proteins and their annotated locations for XP_006245341.1

      UniProtKB/TrEMBL
      A0A8I6A5U2, A6JW06
      Conserved Domains (1) summary
      COG0484
      Location:3 → 110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    6. XM_063267759.1 → XP_063123829.1  dnaJ homolog subfamily B member 2 isoform X6

      UniProtKB/TrEMBL
      A6JW06, B2RYA8

    7. XM_063267755.1 → XP_063123825.1  dnaJ homolog subfamily B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3U5, A6JW06

    8. XM_063267758.1 → XP_063123828.1  dnaJ homolog subfamily B member 2 isoform X5

      UniProtKB/TrEMBL
      A6JW06

    9. XM_063267762.1 → XP_063123832.1  dnaJ homolog subfamily B member 2 isoform X7

      UniProtKB/TrEMBL
      A6JW05, A6JW06, D4ABC2

    10. XM_063267754.1 → XP_063123824.1  dnaJ homolog subfamily B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5U2, A6JW06
      Related
      ENSRNOP00000085337.2, ENSRNOT00000095829.2

    11. XM_063267757.1 → XP_063123827.1  dnaJ homolog subfamily B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3U5, A6JW06

    12. XM_063267761.1 → XP_063123831.1  dnaJ homolog subfamily B member 2 isoform X6

      UniProtKB/TrEMBL
      A6JW06, B2RYA8
    Nucleotide Protein Strain
    Heading Accession and Version

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