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    Aldoa aldolase, fructose-bisphosphate A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24189, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aldoaprovided by RGD
    Official Full Name
    aldolase, fructose-bisphosphate Aprovided by RGD
    Primary source
    RGD:2089
    See related
    EnsemblRapid:ENSRNOG00000052802 AllianceGenome:RGD:2089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aldo1; RNALDOG5
    Summary
    Predicted to enable several functions, including fructose binding activity; fructose-bisphosphate aldolase activity; and identical protein binding activity. Involved in several processes, including methylglyoxal biosynthetic process; response to estrogen; and response to lipopolysaccharide. Located in cytoplasm and heterochromatin. Orthologous to human ALDOA (aldolase, fructose-bisphosphate A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 41307.8), Heart (RPKM 6179.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aldoa in Genome Data Viewer
    Location:
    1q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190832820..190838021, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181402275..181407476, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198228387..198233988, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene yippee-like 3 Neighboring gene T-box transcription factor 6 Neighboring gene protein phosphatase 4, catalytic subunit Neighboring gene uncharacterized LOC103691235 Neighboring gene U6 spliceosomal RNA Neighboring gene TLC domain containing 3B Neighboring gene uncharacterized LOC134483857

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential activation of some transcription factors during rat liver ischemia, reperfusion, and heat shock. Tacchini L, et al. J Cell Physiol, 1999 Aug. PMID 10395295
    2. Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine. Dukes AA, et al. J Neurochem, 2008 Jul. PMID 18384645, Free PMC Article
    3. Aldolase A is present in smooth muscle cell nuclei. Mamczur P, et al. Acta Biochim Pol, 2008. PMID 19081846
    4. LPS increases hepatic HIF-1alpha protein and expression of the HIF-1-dependent gene aldolase A in rats. Scharte M, et al. J Surg Res, 2006 Oct. PMID 16930621
    5. Proteins differentially expressed in response to nicotine in five rat brain regions: identification using a 2-DE/MS-based proteomics approach. Hwang YY, et al. Proteomics, 2006 May. PMID 16622831

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data identified glycolytic enzymes GAPDH and aldolase A as putative interacting proteins for cardiac ATP-sensitive potassium (K(ATP)) channels.
      Title: Cardiac ATP-sensitive K+ channel associates with the glycolytic enzyme complex.
    2. In PC12 cells, DA exposure leads to a cellular response indicative of ER stress prior to the onset of cell death, providing a potential link between DA and the unfolded protein response in the pathogenesis of Parkinson's disease.
      Title: Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine.
    3. Data indicate the presence of a modulated interaction between fructose-1,6-bisphosphatase and aldolase B, and suggest that in kidney, aldolase B specifically participates in gluconeogenesis and with aldolase A in glycolysis.
      Title: Different involvement for aldolase isoenzymes in kidney glucose metabolism: aldolase B but not aldolase A colocalizes and forms a complex with FBPase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fructose binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fructose-bisphosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-bisphosphate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-bisphosphate aldolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fructose-bisphosphate aldolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fructose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methylglyoxal biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nicotine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in I band IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in M band IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fructose-bisphosphate aldolase A
    Names
    aldolase A, fructose-bisphosphate
    muscle-type aldolase
    NP_001170776.1
    NP_001258465.1
    NP_036627.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177305.1 → NP_001170776.1  fructose-bisphosphate aldolase A

      See identical proteins and their annotated locations for NP_001170776.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      CO383722, CO398643, M14420
      UniProtKB/Swiss-Prot
      P05065, Q63038
      UniProtKB/TrEMBL
      A0A8L2R123, A6I9E6
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    2. NM_001271536.1 → NP_001258465.1  fructose-bisphosphate aldolase A

      See identical proteins and their annotated locations for NP_001258465.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      CB750468, CF975930, FQ228954, FQ229100, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P05065, Q63038
      UniProtKB/TrEMBL
      A0A8L2R123, A6I9E6
      Related
      ENSRNOP00000069540.3, ENSRNOT00000088473.3
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    3. NM_012495.2 → NP_036627.1  fructose-bisphosphate aldolase A

      See identical proteins and their annotated locations for NP_036627.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      BC064440, CO383722, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P05065, Q63038
      UniProtKB/TrEMBL
      A0A8L2R123, A6I9E6
      Related
      ENSRNOP00000093578.2, ENSRNOT00000112001.2
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190832820..190838021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05065.2 GenPept UniProtKB/Swiss-Prot:P05065

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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