Rps6kb2 ribosomal protein S6 kinase B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rps6kb2provided by RGD
Official Full Name: ribosomal protein S6 kinase B2provided by RGD
Primary source: RGD:1305144
See related: EnsemblRapid:ENSRNOG00000021689 AllianceGenome:RGD:1305144
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ATP binding activity; peptide binding activity; and ribosomal protein S6 kinase activity. Involved in protein phosphorylation. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RPS6KB2 (ribosomal protein S6 kinase B2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 101.7), Lung (RPKM 72.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (210880824..210887556, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (201451265..201458096, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (219406201..219412888, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

insulin resistance is associated with alterations in the ability of muscle to activate p70S6k signaling following an acute bout of exercise
Title: Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction.
RSK2 is a critical upstream signaling element in the activation of PLD1 to produce the lipids required for exocytosis
Title: The Coffin-Lowry syndrome-associated protein RSK2 controls neuroendocrine secretion through the regulation of phospholipase D1 at the exocytotic sites.
RSK2 is an essential modulator of PLD1 activity in calcium-regulated exocytosis.
Title: The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1.
Thus, proteins in the mTOR/p70S6K pathway are modulated in chronic MK-801 animal models.
Title: The effect of MK-801 on mTOR/p70S6K and translation-related proteins in rat frontal cortex.
phosphorylation of p70(s6k), likely via the Insulin-Like Growth Factor I pathway, may play an important role in androgen-induced skeletal muscle hypertrophy
Title: Phosphorylation of p70s6 kinase is implicated in androgen-induced levator ani muscle anabolism in castrated rats.
p122RhoGAP Ser-322 acts as an integrator of signal transduction in a manner dependent on the cellular context and is a substrate for protein kinase B and ribosomal S6 kinase
Title: Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.
PKCalpha is implicated in CCK-induced activation of p70 S6 kinase in pancreatic acinar AR42J cells.
Title: Protein kinase Calpha is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143074 (e-PCR)
- UniSTS:232321

RH136952 (e-PCR)
- UniSTS:219041

RH128854 (e-PCR)
- UniSTS:212162

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribosomal protein S6 kinase beta-2

Names: ribosomal protein S6 kinase, 70kDa, polypeptide 2; ribosomal protein S6 kinase, polypeptide 2

NP_001010962.2

EC 2.7.11.1

XP_038939718.1

EC 2.7.11.1

XP_038939724.1

EC 2.7.11.1

XP_063124245.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001010962.2 → NP_001010962.2 ribosomal protein S6 kinase beta-2

See identical proteins and their annotated locations for NP_001010962.2

Status: VALIDATED

Source sequence(s)

AW144793, CK843568, DY315655, DY561917

UniProtKB/TrEMBL

A6HYU9, D4AE24

Related

ENSRNOP00000068647.2, ENSRNOT00000083204.3

Conserved Domains (1) summary

cd05584
Location:70 → 392

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

210880824..210887556 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268175.1 → XP_063124245.1 ribosomal protein S6 kinase beta-2 isoform X1

UniProtKB/TrEMBL

D4AE24

Related

ENSRNOP00000029993.6, ENSRNOT00000029580.7
XM_039083796.2 → XP_038939724.1 ribosomal protein S6 kinase beta-2 isoform X2

Conserved Domains (1) summary

cl21453
Location:1 → 192

PKc_like; Protein Kinases, catalytic domain
XM_039083790.2 → XP_038939718.1 ribosomal protein S6 kinase beta-2 isoform X2

Conserved Domains (1) summary

cl21453
Location:1 → 192

PKc_like; Protein Kinases, catalytic domain