Scamp5 secretory carrier membrane protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Scamp5provided by RGD
Full Name: secretory carrier membrane protein 5provided by RGD
Primary source: RGD:68356
See related: EnsemblRapid:ENSRNOG00000054008 AllianceGenome:RGD:68356
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in regulation of synaptic vesicle endocytosis. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Orthologous to human SCAMP5 (secretory carrier membrane protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 75.5), Kidney (RPKM 25.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (66739794..66778538, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (57845831..57884516, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (62221820..62266269, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment to synaptic vesicles during synaptic plasticity.
Title: SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment to synaptic vesicles during synaptic plasticity.
Knockdown of SCAMP5 severely impairs synaptic vesicle endocytosis during stimulation.
Title: SCAMP5 plays a critical role in synaptic vesicle endocytosis during high neuronal activity.
exposure to ER stress increases SCAMP5 in the striatum, which positively regulates mtHTT aggregation via the endocytosis pathway
Title: SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition.
SCAMP isoforms regulate membrane fusion and dense core vesicle exocytosis in neurons.
Title: Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion-dependent exocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion-dependent exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secretory carrier-associated membrane protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429251.1 → NP_001416180.1 secretory carrier-associated membrane protein 5 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2K464, A0A0G2K806, A6J4V3
NM_001429252.1 → NP_001416181.1 secretory carrier-associated membrane protein 5 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_031726.3 → NP_113914.2 secretory carrier-associated membrane protein 5 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2K464, A0A0G2K806, A6J4V3

Related

ENSRNOP00000074421.2, ENSRNOT00000089602.3

Conserved Domains (1) summary

pfam04144
Location:6 → 179

SCAMP; SCAMP family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

66739794..66778538 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595896.3 → XP_017451385.1 secretory carrier-associated membrane protein 5 isoform X1

Conserved Domains (1) summary

pfam04144
Location:6 → 179

SCAMP; SCAMP family
XM_039082103.2 → XP_038938031.1 secretory carrier-associated membrane protein 5 isoform X3

Conserved Domains (1) summary

pfam04144
Location:44 → 108

SCAMP; SCAMP family
XM_039082104.2 → XP_038938032.1 secretory carrier-associated membrane protein 5 isoform X3

Conserved Domains (1) summary

pfam04144
Location:44 → 108

SCAMP; SCAMP family
XM_017595898.3 → XP_017451387.1 secretory carrier-associated membrane protein 5 isoform X1

UniProtKB/TrEMBL

A0A0G2K464, A0A0G2K806, A6J4V3

Conserved Domains (1) summary

pfam04144
Location:6 → 179

SCAMP; SCAMP family
XM_039082105.2 → XP_038938033.1 secretory carrier-associated membrane protein 5 isoform X3

Conserved Domains (1) summary

pfam04144
Location:44 → 108

SCAMP; SCAMP family
XM_017595897.3 → XP_017451386.1 secretory carrier-associated membrane protein 5 isoform X1

UniProtKB/TrEMBL

A0A0G2K464, A0A0G2K806, A6J4V3

Conserved Domains (1) summary

pfam04144
Location:6 → 179

SCAMP; SCAMP family
XM_017595899.3 → XP_017451388.1 secretory carrier-associated membrane protein 5 isoform X1

UniProtKB/TrEMBL

A0A0G2K464, A0A0G2K806, A6J4V3

Conserved Domains (1) summary

pfam04144
Location:6 → 179

SCAMP; SCAMP family
XM_063266087.1 → XP_063122157.1 secretory carrier-associated membrane protein 5 isoform X2