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    Clps colipase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25680, updated on 9-Dec-2024

    Summary

    Official Symbol
    Clpsprovided by RGD
    Official Full Name
    colipaseprovided by RGD
    Primary source
    RGD:2363
    See related
    EnsemblRapid:ENSRNOG00000000510 AllianceGenome:RGD:2363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    COLQ
    Summary
    Enables enzyme activator activity. Involved in positive regulation of catalytic activity; post-embryonic development; and response to food. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CLPS (colipase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1512.3) See more
    Orthologs
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    Genomic context

    See Clps in Genome Data Viewer
    Location:
    20p12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6622234..6624414, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6620529..6622709, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5803447..5806107, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 12 Neighboring gene colipase-like 2 Neighboring gene LHFPL tetraspan subfamily member 5 Neighboring gene SRSF protein kinase 1 Neighboring gene uncharacterized LOC120098971

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme activator activity PubMed 
    enables enzyme activator activity  
    enables lipase binding  
    Process Evidence Code Pubs
    involved_in digestion  
    involved_in lipid catabolic process  
    involved_in positive regulation of catalytic activity PubMed 
    involved_in post-embryonic development PubMed 
    involved_in response to bacterium  
    acts_upstream_of_or_within response to bacterium  
    involved_in response to food  
    involved_in response to food PubMed 
    Component Evidence Code Pubs
    located_in extracellular region  

    General protein information

    Preferred Names
    colipase
    Names
    colipase, pancreatic

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013139.2NP_037271.2  colipase precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P17084
      UniProtKB/TrEMBL
      F1LNA9
      Related
      ENSRNOP00000000611.3, ENSRNOT00000000611.6
      Conserved Domains (1) summary
      smart00023
      Location:18112
      COLIPASE; Colipase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      6622234..6624414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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