Lifr LIF receptor subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lifrprovided by RGD
Official Full Name: LIF receptor subunit alphaprovided by RGD
Primary source: RGD:621431
See related: EnsemblRapid:ENSRNOG00000011696 AllianceGenome:RGD:621431
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cytokine binding activity and leukemia inhibitory factor receptor activity. Involved in several processes, including animal organ regeneration; negative regulation of muscle cell apoptotic process; and neuron projection morphogenesis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 952.8), Kidney (RPKM 679.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (57951787..58020357)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (56224393..56292988)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (56424910..56489346)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lifr plays a pivotal role in the astrocyte apoptosis induced by hypoxic/low-glucose environments.
Title: Leukemia Inhibitory Factor Receptor Is Involved in Apoptosis in Rat Astrocytes Exposed to Oxygen-Glucose Deprivation.
In the chronic kidney disease-cardiac hypertrophy model exercise rescues cardiac disease via cardiotrophin-1/LIFR/gp 130/JAK/STAT3 pathway.
Title: Exercise rescued chronic kidney disease by attenuating cardiac hypertrophy through the cardiotrophin-1 -> LIFR/gp 130 -> JAK/STAT3 pathway.
LIF and its subunit receptor LIFRalpha are constitutively expressed during fetal lung development and that they have an inhibitory physiological role on fetal lung branching.
Title: Leukemia inhibitory factor in rat fetal lung development: expression and functional studies.
continuous orthodontic forces induce the upregulation of production, suggesting that LIFR may play important role in periodontium remodeling
Title: Expression of LIF and LIFR in periodontal tissue during orthodontic tooth movement.
tumor necrosis factor alpha (TNF) regulates the expression of the leukemia inhibitor factor receptor (LIFR) gp190 in RBE4 cells
Title: Opposing effects of proteasomes and lysosomes on LIFR: modulation by TNF.
LIFR signaling can exert negative regulatory effects on neurite extension and branching of sympathetic neurons
Title: Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons.
Leukemia inhibitory factor receptor and gp130 were expressed in neurons, and the ischemic damage of these proteins was rescued in the high-LIF group
Title: Activation of cytokine signaling through leukemia inhibitory factor receptor (LIFR)/gp130 attenuates ischemic brain injury in rats.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to ciliary neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables ciliary neurotrophic factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ciliary neurotrophic factor receptor binding	IEA Inferred from Electronic Annotation more info
enables ciliary neurotrophic factor receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables leukemia inhibitory factor receptor activity	IEA Inferred from Electronic Annotation more info
enables leukemia inhibitory factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to leukemia inhibitory factor receptor activity	ISO Inferred from Sequence Orthology more info
enables leukemia inhibitory factor receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to oncostatin-M receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables oncostatin-M receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to oncostatin-M receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ciliary neurotrophic factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leukemia inhibitory factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leukemia inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in oncostatin-M-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in oncostatin-M-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leukemia inhibitory factor receptor

Names: LIF receptor alpha; LIF-R; leukemia inhibitor factor receptor alpha-chain; leukemia inhibitory factor receptor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031048.1 → NP_112310.1 leukemia inhibitory factor receptor precursor

See identical proteins and their annotated locations for NP_112310.1

Status: PROVISIONAL

Source sequence(s)

D86345

UniProtKB/Swiss-Prot

O70535

Conserved Domains (3) summary

cd00063
Location:432 → 526

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:552 → 615

fn3; Fibronectin type III domain

cl21522
Location:332 → 368

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

57951787..58020357

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232029.5 → XP_006232091.1 leukemia inhibitory factor receptor isoform X1

See identical proteins and their annotated locations for XP_006232091.1

UniProtKB/TrEMBL

A6KGG5, G3V7K2

Conserved Domains (4) summary

cd00063
Location:432 → 526

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:127 → 240

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam18207
Location:54 → 125

LIFR_N; Leukemia inhibitory factor receptor N-terminal domain

cl21522
Location:548 → 615

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039103223.2 → XP_038959151.1 leukemia inhibitory factor receptor isoform X1

UniProtKB/TrEMBL

A6KGG5, G3V7K2

Conserved Domains (4) summary

cd00063
Location:432 → 526

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:127 → 240

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam18207
Location:54 → 125

LIFR_N; Leukemia inhibitory factor receptor N-terminal domain

cl21522
Location:548 → 615

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_063282627.1 → XP_063138697.1 leukemia inhibitory factor receptor isoform X1

UniProtKB/TrEMBL

A6KGG5, G3V7K2
XM_006232027.5 → XP_006232089.1 leukemia inhibitory factor receptor isoform X1

See identical proteins and their annotated locations for XP_006232089.1

UniProtKB/TrEMBL

A6KGG5, G3V7K2

Related

ENSRNOP00000016036.2, ENSRNOT00000016036.6

Conserved Domains (4) summary

cd00063
Location:432 → 526

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:127 → 240

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam18207
Location:54 → 125

LIFR_N; Leukemia inhibitory factor receptor N-terminal domain

cl21522
Location:548 → 615

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...