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    Tpra1 transmembrane protein adipocyte associated 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tpra1provided by RGD
    Official Full Name
    transmembrane protein adipocyte associated 1provided by RGD
    Primary source
    RGD:620858
    See related
    EnsemblRapid:ENSRNOG00000016665 AllianceGenome:RGD:620858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr175; Tpra40
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within embryonic cleavage and negative regulation of mitotic cell cycle phase transition. Located in plasma membrane. Orthologous to human TPRA1 (transmembrane protein adipocyte associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 154.2), Kidney (RPKM 80.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tpra1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (122921304..122932519)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (121364093..121375275)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (120843374..120854534)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene podocalyxin-like 2 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene uncharacterized LOC102554942 Neighboring gene uncharacterized LOC102555035

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of rat transmembrane domain protein of 40 kDa regulated in adipocytes and its expression in H9c2 cells exposed to ischemic hypoxia and reoxygenation. Fujimoto K, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267675
    2. TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14. Aki T, et al. J Cell Physiol, 2008 Oct. PMID 18459117
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic cleavage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic cleavage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein adipocyte-associated 1
    Names
    G protein-coupled receptor 175
    transmembrane domain protein regulated in adipocytes 40 kDa
    transmembrane protein, adipocyte asscociated 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053534.2 → NP_445986.2  transmembrane protein adipocyte-associated 1

      See identical proteins and their annotated locations for NP_445986.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IB54, A6IB55, G3V859
      Related
      ENSRNOP00000022534.3, ENSRNOT00000022534.8
      Conserved Domains (1) summary
      pfam10160
      Location:36 → 310
      Tmemb_40; Predicted membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      122921304..122932519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236868.5 → XP_006236930.1  transmembrane protein adipocyte-associated 1 isoform X1

      See identical proteins and their annotated locations for XP_006236930.1

      UniProtKB/TrEMBL
      A6IB54, A6IB55, G3V859
      Conserved Domains (1) summary
      pfam10160
      Location:36 → 310
      Tmemb_40; Predicted membrane protein

    2. XM_017592933.3 → XP_017448422.1  transmembrane protein adipocyte-associated 1 isoform X1

      UniProtKB/TrEMBL
      A6IB54, A6IB55, G3V859
      Conserved Domains (1) summary
      pfam10160
      Location:36 → 310
      Tmemb_40; Predicted membrane protein

    3. XM_039108488.2 → XP_038964416.1  transmembrane protein adipocyte-associated 1 isoform X2

      Conserved Domains (1) summary
      pfam10160
      Location:5 → 211
      Tmemb_40; Predicted membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q791F6.1 GenPept UniProtKB/Swiss-Prot:Q791F6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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