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    Myh8 myosin heavy chain 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252942, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myh8provided by RGD
    Official Full Name
    myosin heavy chain 8provided by RGD
    Primary source
    RGD:620356
    See related
    EnsemblRapid:ENSRNOG00000068010 AllianceGenome:RGD:620356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and microfilament motor activity. Predicted to be involved in ATP metabolic process; muscle filament sliding; and skeletal muscle contraction. Predicted to be located in cytoplasm. Predicted to be part of myosin complex. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; disease of cellular proliferation; and distal arthrogryposis type 7. Orthologous to human MYH8 (myosin heavy chain 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 11166.8) See more
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    Genomic context

    See Myh8 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52462509..52492105)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (51963510..51993103)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (53818818..53848490)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555216 Neighboring gene myosin heavy chain 1 Neighboring gene myosin heavy chain 4 Neighboring gene myosin heavy chain 13 Neighboring gene ATP synthase membrane subunit K, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables actin binding  
    enables actin filament binding  
    enables cytoskeletal motor activity  
    enables microfilament motor activity  
    enables microfilament motor activity  
    Process Evidence Code Pubs
    involved_in ATP metabolic process  
    involved_in ATP metabolic process  
    involved_in biological_process  
    involved_in muscle filament sliding  
    involved_in muscle filament sliding  
    involved_in skeletal muscle contraction  
    involved_in skeletal muscle contraction  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in myofibril  
    part_of myosin complex  
    part_of myosin complex  
    located_in myosin filament  

    General protein information

    Preferred Names
    myosin-8
    Names
    myHC-perinatal
    myosin heavy chain, skeletal muscle, perinatal
    myosin, heavy chain 8, skeletal muscle, perinatal
    myosin, heavy polypeptide 8, skeletal muscle, perinatal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100485.1NP_001093955.1  myosin-8

      See identical proteins and their annotated locations for NP_001093955.1

      Status: VALIDATED

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I5Y7Z0, A6HFI4
      Related
      ENSRNOP00000077580.2, ENSRNOT00000105953.2
      Conserved Domains (8) summary
      cl22853
      Location:102769
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:90769
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8491926
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3875
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam06273
      Location:10421099
      eIF-4B; Plant specific eukaryotic initiation factor 4B
      pfam07851
      Location:14561584
      TMPIT; TMPIT-like protein
      cl19764
      Location:13751510
      COG6; Conserved oligomeric complex COG6
      cl23720
      Location:9641097
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      52462509..52492105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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