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    Aebp1 AE binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305494, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aebp1provided by RGD
    Official Full Name
    AE binding protein 1provided by RGD
    Primary source
    RGD:1306922
    See related
    EnsemblRapid:ENSRNOG00000013720 AllianceGenome:RGD:1306922
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; collagen binding activity; and metallocarboxypeptidase activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; protein processing; and regulation of collagen fibril organization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome classic-like 2. Orthologous to human AEBP1 (AE binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 322.8), Uterus (RPKM 269.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Aebp1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84951577..84962840)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80738800..80748878)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86101253..86111323)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096651 Neighboring gene DNA polymerase mu Neighboring gene DNA polymerase delta 2, accessory subunit Neighboring gene uncharacterized LOC108352788

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables calmodulin binding  
    enables carboxypeptidase activity  
    enables collagen binding  
    enables collagen binding  
    enables collagen binding  
    NOT enables metallocarboxypeptidase activity  
    enables metallocarboxypeptidase activity  
    enables zinc ion binding  

    General protein information

    Preferred Names
    adipocyte enhancer-binding protein 1
    Names
    aortic carboxypeptidase-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100970.1NP_001094440.1  adipocyte enhancer-binding protein 1 precursor

      See identical proteins and their annotated locations for NP_001094440.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133065
      UniProtKB/Swiss-Prot
      A2RUV9
      UniProtKB/TrEMBL
      A6IKQ1
      Conserved Domains (4) summary
      cd03869
      Location:552895
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:899974
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:376532
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:378531
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      84951577..84962840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273226.1XP_063129296.1  adipocyte enhancer-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A2RUV9
      UniProtKB/TrEMBL
      A6IKQ1
    2. XM_006251316.5XP_006251378.1  adipocyte enhancer-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHL3, A6IKQ1
      Related
      ENSRNOP00000018846.8, ENSRNOT00000018846.8
      Conserved Domains (4) summary
      cd03869
      Location:551894
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:898973
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:375531
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:377530
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
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