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    Anapc4 anaphase promoting complex subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305420, updated on 9-Dec-2024

    Summary

    Official Symbol
    Anapc4provided by RGD
    Official Full Name
    anaphase promoting complex subunit 4provided by RGD
    Primary source
    RGD:1306572
    See related
    EnsemblRapid:ENSRNOG00000004130 AllianceGenome:RGD:1306572
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein phosphatase binding activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process and protein polyubiquitination. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Predicted to be active in nuclear periphery. Orthologous to human ANAPC4 (anaphase promoting complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 183.6), Lung (RPKM 159.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Anapc4 in Genome Data Viewer
    Location:
    14q11
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (62338798..62370572, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (58125995..58159253, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (60471962..60503803, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096615 Neighboring gene solute carrier family 34 member 2 Neighboring gene eukaryotic translation initiation factor 4E family member 2, pseudogene 1 Neighboring gene zinc finger CCHC-type containing 4 Neighboring gene uncharacterized LOC134481754 Neighboring gene phosphatidylinositol 4-kinase type 2 beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of anaphase-promoting complex  
    part_of anaphase-promoting complex  
    is_active_in nuclear periphery  
    located_in nucleus  

    General protein information

    Preferred Names
    anaphase-promoting complex subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107220.1NP_001100690.1  anaphase-promoting complex subunit 4

      See identical proteins and their annotated locations for NP_001100690.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473963
      UniProtKB/TrEMBL
      A0A8I5ZJP1, A6IJG7, D3ZUB7
      Related
      ENSRNOP00000006093.3, ENSRNOT00000006093.6
      Conserved Domains (3) summary
      sd00039
      Location:2459
      7WD40; WD40 repeat [structural motif]
      pfam12894
      Location:26118
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam12896
      Location:232431
      ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      62338798..62370572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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