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    Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65248, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prkaa1provided by RGD
    Official Full Name
    protein kinase AMP-activated catalytic subunit alpha 1provided by RGD
    Primary source
    RGD:3387
    See related
    EnsemblRapid:ENSRNOG00000012799 AllianceGenome:RGD:3387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AMPKalpha1
    Summary
    Enables AMP-activated protein kinase activity and ATP binding activity. Involved in several processes, including cellular response to ethanol; cold acclimation; and fatty acid homeostasis. Located in several cellular components, including apical plasma membrane; dendrite; and neuronal cell body. Part of nucleotide-activated protein kinase complex. Used to study type 2 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 151.7), Kidney (RPKM 114.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Prkaa1 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (55967766..56003450)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (54240298..54275978)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (54857688..54893404)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 6 Neighboring gene small nucleolar RNA, C/D box 72 Neighboring gene ribosomal protein L37 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 5 Neighboring gene uncharacterized LOC120100730 Neighboring gene prostaglandin E receptor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 39
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity PubMed 
    enables AMP-activated protein kinase activity  
    enables AMP-activated protein kinase activity PubMed 
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity  
    enables chromatin binding  
    enables chromatin binding  
    enables eukaryotic elongation factor-2 kinase activator activity PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding PubMed 
    enables ribosomal protein S6 kinase activity  
    enables tau-protein kinase activity  
    Items 1 - 25 of 39
    Items 1 - 25 of 87
    Process Evidence Code Pubs
    involved_in CAMKK-AMPK signaling cascade  
    involved_in Wnt signaling pathway  
    involved_in autophagy  
    involved_in cellular response to calcium ion PubMed 
    involved_in cellular response to calcium ion  
    involved_in cellular response to ethanol PubMed 
    involved_in cellular response to glucose starvation  
    involved_in cellular response to glucose starvation  
    involved_in cellular response to glucose starvation  
    involved_in cellular response to glucose stimulus PubMed 
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to hydrogen peroxide PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to nutrient levels  
    involved_in cellular response to nutrient levels  
    involved_in cellular response to oxidative stress  
    acts_upstream_of_or_within cellular response to prostaglandin E stimulus  
    involved_in cellular response to stress  
    involved_in cellular response to xenobiotic stimulus PubMed 
    involved_in cholesterol biosynthetic process  
    involved_in chromatin remodeling  
    involved_in cold acclimation PubMed 
    involved_in energy homeostasis PubMed 
    involved_in energy homeostasis  
    involved_in fatty acid biosynthetic process  
    involved_in fatty acid homeostasis PubMed 
    acts_upstream_of_or_within fatty acid oxidation  
    involved_in glucose homeostasis  
    involved_in glucose homeostasis  
    acts_upstream_of_or_within glucose metabolic process  
    involved_in lipid biosynthetic process  
    involved_in lipid biosynthetic process  
    acts_upstream_of_positive_effect lipid droplet disassembly  
    acts_upstream_of_positive_effect lipid droplet disassembly  
    involved_in motor behavior  
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of hepatocyte apoptotic process  
    involved_in negative regulation of hepatocyte apoptotic process  
    involved_in negative regulation of insulin receptor signaling pathway PubMed 
    involved_in negative regulation of lipid catabolic process  
    involved_in negative regulation of lipid catabolic process  
    involved_in negative regulation of translation PubMed 
    involved_in negative regulation of tubulin deacetylation  
    involved_in neuron cellular homeostasis  
    involved_in positive regulation of D-glucose import PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of T cell activation  
    involved_in positive regulation of T cell mediated immune response to tumor cell  
    involved_in positive regulation of adipose tissue development  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of fatty acid oxidation PubMed 
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of gluconeogenesis PubMed 
    involved_in positive regulation of glycolytic process PubMed 
    involved_in positive regulation of mitochondrial transcription  
    involved_in positive regulation of peptidyl-lysine acetylation  
    involved_in positive regulation of protein localization  
    involved_in positive regulation of protein targeting to mitochondrion  
    acts_upstream_of_or_within positive regulation of skeletal muscle tissue development  
    involved_in protein localization to lipid droplet  
    involved_in protein localization to lipid droplet  
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of microtubule cytoskeleton organization  
    acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation  
    involved_in regulation of stress granule assembly  
    involved_in regulation of vesicle-mediated transport PubMed 
    involved_in response to UV  
    involved_in response to activity PubMed 
    involved_in response to caffeine PubMed 
    involved_in response to estrogen PubMed 
    involved_in response to gamma radiation  
    involved_in response to gamma radiation  
    involved_in response to hydrogen peroxide  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in rhythmic process  
    Items 1 - 25 of 87
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in axon PubMed 
    located_in axon  
    is_active_in chromatin  
    located_in chromatin  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in dendrite  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    located_in nuclear speck  
    located_in nuclear speck  
    part_of nucleotide-activated protein kinase complex  
    part_of nucleotide-activated protein kinase complex PubMed 
    part_of nucleotide-activated protein kinase complex  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    part_of protein-containing complex PubMed 
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    5'-AMP-activated protein kinase catalytic subunit alpha-1
    Names
    ACACA kinase
    AMPK alpha-1 chain
    HMGCR kinase
    acetyl-CoA carboxylase kinase
    hydroxymethylglutaryl-CoA reductase kinase
    protein kinase, AMP-activated, alpha 1 catalytic subunit
    tau-protein kinase PRKAA1
    NP_062015.2
    XP_038959025.1
    XP_063138576.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019142.4NP_062015.2  5'-AMP-activated protein kinase catalytic subunit alpha-1

      See identical proteins and their annotated locations for NP_062015.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P54645
      UniProtKB/TrEMBL
      A6KGD8
      Related
      ENSRNOP00000017626.4, ENSRNOT00000017626.7
      Conserved Domains (3) summary
      cd12199
      Location:404557
      AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
      cd14403
      Location:296360
      UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
      cd14079
      Location:24279
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      55967766..56003450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103097.2XP_038959025.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GCD0
      Conserved Domains (3) summary
      cd12199
      Location:320473
      AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
      cd14403
      Location:212276
      UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
      cl21453
      Location:7195
      PKc_like; Protein Kinases, catalytic domain
    2. XM_063282506.1XP_063138576.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GCD0
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