U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Nrarp Notch-regulated ankyrin repeat protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499745, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nrarpprovided by RGD
    Official Full Name
    Notch-regulated ankyrin repeat proteinprovided by RGD
    Primary source
    RGD:1591939
    See related
    EnsemblRapid:ENSRNOG00000009354 AllianceGenome:RGD:1591939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in angiogenesis; positive regulation of endothelial cell proliferation; and regulation of signal transduction. Predicted to act upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial cell proliferation; and somite rostral/caudal axis specification. Orthologous to human NRARP (NOTCH regulated ankyrin repeat protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nrarp in Genome Data Viewer
    Location:
    3p13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28390745..28393299)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7992582..7995136)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2396143..2398697)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 8 Neighboring gene NADPH oxidase activator 1 Neighboring gene uncharacterized LOC134486058 Neighboring gene 60S ribosomal protein L23-like Neighboring gene torsin family 4, member A Neighboring gene negative elongation factor complex member B Neighboring gene RNA, U6 small nuclear 136

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of Notch signaling pathway  
    involved_in Notch signaling pathway  
    acts_upstream_of T cell differentiation  
    involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
    acts_upstream_of_or_within blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
    involved_in branching involved in blood vessel morphogenesis  
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis  
    acts_upstream_of endothelial cell proliferation  
    involved_in negative regulation of Notch signaling pathway  
    acts_upstream_of_or_within negative regulation of Notch signaling pathway  
    acts_upstream_of_or_within negative regulation of T cell differentiation  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of endothelial cell proliferation  
    acts_upstream_of_or_within positive regulation of vascular endothelial cell proliferation  
    involved_in protein targeting to chloroplast  
    acts_upstream_of_or_within regulation of cell-cell adhesion  
    acts_upstream_of_or_within somite rostral/caudal axis specification  
    acts_upstream_of_or_within sprouting angiogenesis  
    acts_upstream_of vascular endothelial cell proliferation  
    acts_upstream_of_or_within vascular endothelial cell proliferation  

    General protein information

    Preferred Names
    notch-regulated ankyrin repeat-containing protein
    Names
    Maternal Effect Lethal family member (mel-11)-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143750.1NP_001137222.1  notch-regulated ankyrin repeat-containing protein

      See identical proteins and their annotated locations for NP_001137222.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3Z9S9
      Related
      ENSRNOP00000058835.1, ENSRNOT00000012388.6
      Conserved Domains (2) summary
      sd00045
      Location:5081
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:21106
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28390745..28393299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.