U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Ccnd1 cyclin D1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58919, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccnd1provided by RGD
    Official Full Name
    cyclin D1provided by RGD
    Primary source
    RGD:68384
    See related
    EnsemblRapid:ENSRNOG00000020918 AllianceGenome:RGD:68384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein kinase binding activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and response to vitamin E. Predicted to be located in bicellular tight junction and nucleoplasm. Predicted to be part of cyclin D1-CDK4 complex; cyclin D1-CDK6 complex; and transcription repressor complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Used to study prostate cancer and status epilepticus. Biomarker of several diseases, including atherosclerosis; impotence; interstitial cystitis; liver cancer; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 417.0), Lung (RPKM 379.3) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ccnd1 in Genome Data Viewer
    Location:
    1q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (209518288..209527986, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (200089002..200098524, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (218090750..218100447, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10, pseudogene 18 Neighboring gene LTO1 maturation factor of ABCE1 Neighboring gene brain cytoplasmic RNA 1 Neighboring gene uncharacterized LOC120099967 Neighboring gene uncharacterized LOC108349679

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity  
    enables cyclin-dependent protein serine/threonine kinase activator activity  
    enables cyclin-dependent protein serine/threonine kinase regulator activity  
    enables cyclin-dependent protein serine/threonine kinase regulator activity  
    enables enzyme binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables kinase activity  
    enables proline-rich region binding  
    enables proline-rich region binding  
    enables protein kinase activity  
    enables protein kinase activity  
    enables protein kinase binding  
    enables protein kinase binding PubMed 
    enables protein kinase binding  
    enables protein-containing complex binding PubMed 
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    Items 1 - 25 of 76
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle PubMed 
    involved_in Leydig cell differentiation PubMed 
    involved_in Wnt signaling pathway  
    acts_upstream_of_or_within Wnt signaling pathway  
    involved_in animal organ regeneration PubMed 
    involved_in cell division  
    acts_upstream_of_or_within cell population proliferation  
    involved_in endoplasmic reticulum unfolded protein response  
    acts_upstream_of_or_within endoplasmic reticulum unfolded protein response  
    involved_in fat cell differentiation  
    acts_upstream_of_or_within fat cell differentiation  
    involved_in lactation  
    acts_upstream_of_or_within lactation  
    involved_in liver development PubMed 
    involved_in liver regeneration  
    acts_upstream_of_or_within liver regeneration  
    involved_in mammary gland alveolus development  
    acts_upstream_of_or_within mammary gland alveolus development  
    involved_in mammary gland epithelial cell proliferation  
    acts_upstream_of mammary gland epithelial cell proliferation  
    acts_upstream_of_or_within mammary gland epithelial cell proliferation  
    involved_in mitotic G1 DNA damage checkpoint signaling  
    involved_in mitotic G1 DNA damage checkpoint signaling  
    involved_in mitotic G1 DNA damage checkpoint signaling  
    involved_in negative regulation of epithelial cell differentiation  
    involved_in negative regulation of epithelial cell differentiation  
    involved_in negative regulation of neuron apoptotic process  
    acts_upstream_of_or_within negative regulation of neuron apoptotic process  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in neuron differentiation  
    acts_upstream_of_or_within neuron differentiation  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in positive regulation of mammary gland epithelial cell proliferation  
    acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein phosphorylation  
    acts_upstream_of_or_within protein phosphorylation  
    involved_in re-entry into mitotic cell cycle  
    acts_upstream_of_or_within re-entry into mitotic cell cycle  
    acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle  
    acts_upstream_of_or_within regulation of cell cycle  
    involved_in response to UV-A  
    involved_in response to UV-A  
    involved_in response to UV-A  
    involved_in response to X-ray PubMed 
    involved_in response to calcium ion PubMed 
    involved_in response to corticosterone PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to estrogen PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to iron ion PubMed 
    involved_in response to leptin  
    involved_in response to leptin  
    involved_in response to magnesium ion PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to steroid hormone PubMed 
    involved_in response to vitamin E PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to xenobiotic stimulus  
    Items 1 - 25 of 76
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    part_of cyclin D1-CDK4 complex  
    part_of cyclin D1-CDK4 complex  
    part_of cyclin D1-CDK6 complex  
    part_of cyclin D1-CDK6 complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in microtubule organizing center  
    located_in nuclear membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    is_active_in nucleus  
    located_in nucleus  
    part_of transcription repressor complex  
    part_of transcription repressor complex  
    part_of transcription repressor complex  
    Items 1 - 20 of 23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_171992.6NP_741989.3  G1/S-specific cyclin-D1

      See identical proteins and their annotated locations for NP_741989.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P39948
      UniProtKB/TrEMBL
      A6HYI6, A6HYI8
      Related
      ENSRNOP00000075372.3, ENSRNOT00000088588.3
      Conserved Domains (2) summary
      cd20573
      Location:3151
      CYCLIN_CCND1_rpt1; first cyclin box found in G1/S-specific cyclin-D1 (CCND1)
      cd20576
      Location:156265
      CYCLIN_CCND1_rpt2; second cyclin box found in G1/S-specific cyclin-D1 (CCND1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      209518288..209527986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760168.3XP_008758390.1  G1/S-specific cyclin-D1 isoform X1

      See identical proteins and their annotated locations for XP_008758390.1

      UniProtKB/TrEMBL
      A0A8L2QF92, A6HYI9
      Conserved Domains (2) summary
      pfam00134
      Location:31153
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:156291
      Cyclin_C; Cyclin, C-terminal domain
    External link. Please review our privacy policy.