Cyp51 cytochrome P450, family 51 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp51provided by RGD
Official Full Name: cytochrome P450, family 51provided by RGD
Primary source: RGD:2481
See related: EnsemblRapid:ENSRNOG00000007234 AllianceGenome:RGD:2481
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp51a1; RATCP14DM
Summary: Enables sterol 14-demethylase activity. Involved in several processes, including cholesterol biosynthetic process via 24,25-dihydrolanosterol; positive regulation of oocyte development; and response to human chorionic gonadotropin. Located in acrosomal vesicle. Biomarker of diabetes mellitus. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 913.2), Brain (RPKM 436.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (30991693..31010147)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (30036956..30055410)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (27175564..27194018)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypothyroidism changes CYP51 and FSHR expression in ovary, which are regulated by gonadotropin. Moreover, genes changes in ovary are at least partially attributed to steroids biosynthesis.
Title: Effect of hypothyroidism on CYP51 and FSHR expression in rat ovary.
Follicular fluid meiosis-activating sterol (FF-MAS) is synthesized by cytochrome P450 lanosterol 14alpha-demethylase. The results described here call into question any role of FF-MAS as an obligatory mediator of LH activity on germinal vesicle breakdown.
Title: Meiosis-activating sterol synthesis in rat preovulatory follicle: is it involved in resumption of meiosis?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:256608 (e-PCR)
- UniSTS:256608

Cyp51 (e-PCR), detects polymorphism
- UniSTS:256608

RH129291 (e-PCR)
- UniSTS:212598

Cyp51 (e-PCR), detects polymorphism
- UniSTS:463011

RH128867 (e-PCR)
- UniSTS:212175

RH137266 (e-PCR)
- UniSTS:219354

RH141214 (e-PCR)
- UniSTS:223210

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables sterol 14-demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol 14-demethylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process via 24,25-dihydrolanosterol	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process via 24,25-dihydrolanosterol	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in organic hydroxy compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cholesterol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in response to human chorionic gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in small molecule biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lanosterol 14-alpha demethylase

Names: CYPLI; Cytochrom P450 Lanosterol 14 alpha-demethylase; LDM; P450-14DM; P45014DM; P450LI; cytochrome P450 51A1; cytochrome P450 Lanosterol 14 alpha-demethylase; cytochrome P450, subfamily 51; cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI; sterol 14-alpha demethylase; sterol 14-alpha demethylase P450

NP_037073.1

EC 1.14.14.154

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.