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    Limk2 LIM domain kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29524, updated on 9-Dec-2024

    Summary

    Official Symbol
    Limk2provided by RGD
    Official Full Name
    LIM domain kinase 2provided by RGD
    Primary source
    RGD:62056
    See related
    EnsemblRapid:ENSRNOG00000019000 AllianceGenome:RGD:62056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Link2; Limk2b
    Summary
    Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Predicted to be located in centrosome; cis-Golgi network; and mitotic spindle. Predicted to be active in cytoplasm and nucleus. Orthologous to human LIMK2 (LIM domain kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 42.8), Liver (RPKM 38.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Limk2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82384256..82509755, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78208182..78286106, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83564048..83641996, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 1 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene U7 small nuclear RNA Neighboring gene phosphoinositide-3-kinase interacting protein 1 Neighboring gene ribosomal protein L7, pseudogene 1 Neighboring gene ring finger protein 185 Neighboring gene uncharacterized LOC134481864 Neighboring gene phospholipase A2, group III

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables metal ion binding  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 29
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization  
    involved_in astral microtubule organization  
    involved_in astral microtubule organization  
    involved_in astral microtubule organization  
    involved_in chromatin remodeling  
    involved_in cornea development in camera-type eye  
    acts_upstream_of_or_within cornea development in camera-type eye  
    involved_in establishment of vesicle localization  
    involved_in establishment of vesicle localization  
    involved_in establishment of vesicle localization  
    involved_in head development  
    acts_upstream_of_or_within head development  
    involved_in negative regulation of cilium assembly  
    involved_in negative regulation of cilium assembly  
    involved_in negative regulation of cilium assembly  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein phosphorylation  
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in spermatid development PubMed 
    involved_in spermatogenesis  
    acts_upstream_of_or_within spermatogenesis  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    located_in centrosome  
    located_in centrosome  
    located_in centrosome  
    located_in cis-Golgi network  
    located_in cis-Golgi network  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in mitotic spindle  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in spindle  

    General protein information

    Preferred Names
    LIM domain kinase 2
    Names
    LIM motif-containing protein kinase 2
    LIMK-2
    NP_077049.2
    XP_006251298.1
    XP_008768501.1
    XP_063129069.1
    XP_063129071.1
    XP_063129072.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024135.3NP_077049.2  LIM domain kinase 2

      See identical proteins and their annotated locations for NP_077049.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P53670
      UniProtKB/TrEMBL
      A0A8L2QS45, A6IKA2
      Related
      ENSRNOP00000026032.3, ENSRNOT00000026032.8
      Conserved Domains (5) summary
      cd09465
      Location:67125
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      smart00221
      Location:334601
      STYKc; Protein kinase; unclassified specificity
      cd14222
      Location:337608
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:152236
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:1265
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      82384256..82509755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251236.5XP_006251298.1  LIM domain kinase 2 isoform X2

      See identical proteins and their annotated locations for XP_006251298.1

      UniProtKB/TrEMBL
      A0A8L2QN67, Q5D047
      Related
      ENSRNOP00000108912.1, ENSRNOT00000123429.1
      Conserved Domains (5) summary
      cd09465
      Location:46104
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      smart00221
      Location:313580
      STYKc; Protein kinase; unclassified specificity
      cd14222
      Location:316587
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:131215
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:1544
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    2. XM_063272999.1XP_063129069.1  LIM domain kinase 2 isoform X1

      UniProtKB/TrEMBL
      A6IKA4
      Related
      ENSRNOP00000109319.1, ENSRNOT00000163662.1
    3. XM_008770279.4XP_008768501.1  LIM domain kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QS45
      Conserved Domains (5) summary
      cd09465
      Location:67125
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      smart00221
      Location:334591
      STYKc; Protein kinase; unclassified specificity
      pfam00595
      Location:152236
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:1265
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl21453
      Location:337601
      PKc_like; Protein Kinases, catalytic domain
    4. XM_063273001.1XP_063129071.1  LIM domain kinase 2 isoform X4

    5. XM_063273002.1XP_063129072.1  LIM domain kinase 2 isoform X5

    RNA

    1. XR_010057359.1 RNA Sequence

    2. XR_595861.4 RNA Sequence

    3. XR_010057358.1 RNA Sequence

    4. XR_010057356.1 RNA Sequence

    5. XR_010057360.1 RNA Sequence

    6. XR_010057361.1 RNA Sequence

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