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    Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29738, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnab2provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily A regulatory beta subunit 2provided by RGD
    Primary source
    RGD:61828
    See related
    EnsemblRapid:ENSRNOG00000011550 AllianceGenome:RGD:61828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including NADPH oxidation; myoblast differentiation; and regulation of protein localization to cell surface. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and microtubule. Part of potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 249.8), Thymus (RPKM 121.4) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Kcnab2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168182228..168270760, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162899511..162988057, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169570327..169658875, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103139 Neighboring gene ribosomal protein L22 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene nephrocystin 4 Neighboring gene uncharacterized LOC134479049 Neighboring gene uncharacterized LOC102549399

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity  
    enables aldo-keto reductase (NADPH) activity PubMed 
    enables methylglyoxal reductase (NADPH) (acetol producing) activity  
    enables oxidoreductase activity  
    enables potassium channel regulator activity  
    enables potassium channel regulator activity PubMed 
    enables potassium channel regulator activity  
    enables potassium channel regulator activity  
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables transmembrane transporter binding  
    enables transmembrane transporter binding PubMed 
    enables voltage-gated potassium channel activity  
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    located_in axon PubMed 
    located_in axon  
    located_in axon  
    is_active_in axon initial segment  
    located_in axon terminus  
    located_in cytoplasm  
    located_in cytoplasmic side of plasma membrane PubMed 
    located_in cytoskeleton  
    located_in cytosol PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in juxtaparanode region of axon  
    located_in juxtaparanode region of axon PubMed 
    located_in juxtaparanode region of axon  
    located_in juxtaparanode region of axon  
    located_in membrane  
    located_in microtubule PubMed 
    located_in neuron projection PubMed 
    located_in pinceau fiber PubMed 
    located_in plasma membrane  
    located_in postsynaptic density  
    is_active_in postsynaptic density membrane PubMed 
    is_active_in postsynaptic density membrane PubMed 
    part_of potassium channel complex PubMed 
    located_in synapse  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    voltage-gated potassium channel subunit beta-2
    Names
    K(+) channel subunit beta-2
    kv-beta-2
    potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2
    potassium channel, voltage gated subfamily A regulatory beta subunit 2
    potassium voltage-gated channel, shaker-related subfamily, beta member 2
    NP_059000.1
    XP_017448703.1
    XP_017448704.1
    XP_038965314.1
    XP_063143337.1
    XP_063143338.1
    XP_063143339.1
    XP_063143340.1
    XP_063143341.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429742.1NP_001416671.1  voltage-gated potassium channel subunit beta-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K670
    2. NM_001429743.1NP_001416672.1  voltage-gated potassium channel subunit beta-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K670
    3. NM_001429744.1NP_001416673.1  voltage-gated potassium channel subunit beta-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A0A8L2Q7L3
    4. NM_001429745.1NP_001416674.1  voltage-gated potassium channel subunit beta-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZVX6
    5. NM_001429746.1NP_001416675.1  voltage-gated potassium channel subunit beta-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P62483
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A6IUI6
    6. NM_001429747.1NP_001416676.1  voltage-gated potassium channel subunit beta-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A0A8I6GCY0
    7. NM_001429748.1NP_001416677.1  voltage-gated potassium channel subunit beta-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A0A8I6GCY0
    8. NM_017304.3NP_059000.1  voltage-gated potassium channel subunit beta-2 isoform 5

      See identical proteins and their annotated locations for NP_059000.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P62483
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A6IUI6
      Related
      ENSRNOP00000085478.2, ENSRNOT00000101700.2
      Conserved Domains (1) summary
      cd19141
      Location:38347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      168182228..168270760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593214.3XP_017448703.1  voltage-gated potassium channel subunit beta-2 isoform X1

      Related
      ENSRNOP00000015840.3, ENSRNOT00000015840.5
      Conserved Domains (1) summary
      cd19141
      Location:38363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    2. XM_039109386.2XP_038965314.1  voltage-gated potassium channel subunit beta-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZVX6
      Conserved Domains (1) summary
      cl00470
      Location:1296
      AKR_SF; Aldo-keto reductase (AKR) superfamily
    3. XM_063287270.1XP_063143340.1  voltage-gated potassium channel subunit beta-2 isoform X5

      Related
      ENSRNOP00000082892.2, ENSRNOT00000111948.2
    4. XM_063287268.1XP_063143338.1  voltage-gated potassium channel subunit beta-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVX6
      Related
      ENSRNOP00000081886.1, ENSRNOT00000113173.2
    5. XM_063287269.1XP_063143339.1  voltage-gated potassium channel subunit beta-2 isoform X4

    6. XM_063287267.1XP_063143337.1  voltage-gated potassium channel subunit beta-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVX6
    7. XM_017593215.3XP_017448704.1  voltage-gated potassium channel subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVX6, A0A8L2Q7L3
      Conserved Domains (1) summary
      cd19141
      Location:38363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    8. XM_063287271.1XP_063143341.1  voltage-gated potassium channel subunit beta-2 isoform X7

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