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    Slc16a12 solute carrier family 16, member 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309525, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc16a12provided by RGD
    Official Full Name
    solute carrier family 16, member 12provided by RGD
    Primary source
    RGD:1311468
    See related
    EnsemblRapid:ENSRNOG00000021916 AllianceGenome:RGD:1311468
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MCT 12; RGD1311468
    Summary
    Enables creatine transmembrane transporter activity. Involved in creatine transmembrane transport and creatinine metabolic process. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 986.0), Liver (RPKM 342.5) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Slc16a12 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (241597165..241674821, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (232184004..232262170, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (252976071..253054500, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA71 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1B-like Neighboring gene interferon-induced protein with tetratricopeptide repeats 1 Neighboring gene uncharacterized LOC134485224 Neighboring gene pantothenate kinase 1 Neighboring gene microRNA 107

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables creatine transmembrane transporter activity PubMed 
    enables creatine transmembrane transporter activity  
    enables transmembrane transporter activity  
    enables uniporter activity  
    enables uniporter activity  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    monocarboxylate transporter 12
    Names
    solute carrier family 16 (monocarboxylic acid transporters), member 12
    solute carrier family 16, member 12 (monocarboxylic acid transporter 12)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191637.1NP_001178566.1  monocarboxylate transporter 12

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D4A734
      Related
      ENSRNOP00000104843.1, ENSRNOT00000167047.1
      Conserved Domains (1) summary
      cl26868
      Location:12451
      2A0111; oxalate/formate antiporter family transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      241597165..241674821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589301.3XP_017444790.1  monocarboxylate transporter 12 isoform X1

      UniProtKB/Swiss-Prot
      D4A734
      Conserved Domains (1) summary
      cl26868
      Location:12451
      2A0111; oxalate/formate antiporter family transporter
    2. XM_017589300.3XP_017444789.1  monocarboxylate transporter 12 isoform X1

      UniProtKB/Swiss-Prot
      D4A734
      Related
      ENSRNOP00000038838.3, ENSRNOT00000030024.7
      Conserved Domains (1) summary
      cl26868
      Location:12451
      2A0111; oxalate/formate antiporter family transporter
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