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    Pfdn1 prefoldin subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361310, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pfdn1provided by RGD
    Official Full Name
    prefoldin subunit 1provided by RGD
    Primary source
    RGD:1305603
    See related
    EnsemblRapid:ENSRNOG00000018653 AllianceGenome:RGD:1305603
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable amyloid-beta binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation and protein folding. Predicted to act upstream of or within B cell activation; actin cytoskeleton organization; and brain development. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN1 (prefoldin subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 586.5), Heart (RPKM 395.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pfdn1 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28288210..28341198, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28014145..28067148, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29233987..29290447, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene purine rich element binding protein A Neighboring gene IgA-inducing protein Neighboring gene cysteine-rich transmembrane module containing 1 Neighboring gene heparin-binding EGF-like growth factor Neighboring gene solute carrier family 4 member 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amyloid-beta binding  
    enables protein folding chaperone  
    enables protein folding chaperone  
    enables unfolded protein binding  
    enables unfolded protein binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    part_of prefoldin complex  

    General protein information

    Preferred Names
    prefoldin subunit 1
    Names
    prefoldin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108427.1NP_001101897.1  prefoldin subunit 1

      See identical proteins and their annotated locations for NP_001101897.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473974
      UniProtKB/TrEMBL
      A0A8I6A4I0, A6J311, D3ZX38
      Related
      ENSRNOP00000025353.4, ENSRNOT00000025353.7
      Conserved Domains (1) summary
      pfam01920
      Location:17117
      Prefoldin_2; Prefoldin subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      28288210..28341198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096961.2XP_038952889.1  prefoldin subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3F6
      Related
      ENSRNOP00000085908.1, ENSRNOT00000099632.2
      Conserved Domains (1) summary
      cl09111
      Location:1767
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
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