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    Slc18a2 solute carrier family 18 member A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25549, updated on 4-Jan-2025

    Summary

    Official Symbol
    Slc18a2provided by RGD
    Official Full Name
    solute carrier family 18 member A2provided by RGD
    Primary source
    RGD:3694
    See related
    EnsemblRapid:ENSRNOG00000008890 AllianceGenome:RGD:3694
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MNAT; VMAT2; VMAT-2
    Summary
    Enables several functions, including amine transmembrane transporter activity; heat shock protein binding activity; and monoamine:proton antiporter activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; neurotransmitter uptake; and signal release. Located in several cellular components, including neuronal cell body; secretory vesicle; and terminal bouton. Is active in dopaminergic synapse; postsynapse; and secretory vesicle. Used to study Parkinson's disease and type 1 diabetes mellitus. Biomarker of Machado-Joseph disease; Parkinson's disease; substance-related disorder; and toxic encephalopathy. Human ortholog(s) of this gene implicated in Parkinson's disease and infantile parkinsonism-dystonia 2. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 40.5), Spleen (RPKM 31.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Slc18a2 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (268399815..268435229)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (258413748..258449143)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (280397831..280457968)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ventral anterior homeobox 1 Neighboring gene potassium two pore domain channel subfamily K member 18 Neighboring gene PDZ domain containing 8 Neighboring gene uncharacterized LOC134485265

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 42
    Process Evidence Code Pubs
    involved_in aminergic neurotransmitter loading into synaptic vesicle  
    involved_in aminergic neurotransmitter loading into synaptic vesicle PubMed 
    involved_in aminergic neurotransmitter loading into synaptic vesicle PubMed 
    involved_in cellular response to ammonium ion PubMed 
    involved_in cellular response to xenobiotic stimulus PubMed 
    involved_in endocytic recycling PubMed 
    involved_in histamine secretion by mast cell  
    involved_in histamine secretion by mast cell  
    involved_in histamine uptake PubMed 
    involved_in histamine uptake  
    involved_in histamine uptake  
    involved_in insulin secretion PubMed 
    involved_in locomotory behavior  
    acts_upstream_of_or_within locomotory behavior  
    involved_in monoamine transport PubMed 
    involved_in negative regulation of neurotransmitter transport PubMed 
    involved_in neurotransmitter loading into synaptic vesicle  
    involved_in neurotransmitter loading into synaptic vesicle  
    involved_in neurotransmitter transport PubMed 
    involved_in post-embryonic development  
    acts_upstream_of_or_within post-embryonic development  
    involved_in proton transmembrane transport  
    involved_in response to amphetamine  
    involved_in response to amphetamine PubMed 
    acts_upstream_of_or_within response to amphetamine  
    involved_in response to cocaine PubMed 
    involved_in response to corticosterone PubMed 
    involved_in response to herbicide PubMed 
    involved_in response to metal ion PubMed 
    involved_in response to starvation PubMed 
    involved_in response to toxic substance  
    acts_upstream_of_or_within response to toxic substance  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to zinc ion PubMed 
    involved_in serotonin secretion by mast cell  
    involved_in serotonin secretion by mast cell  
    involved_in serotonin uptake PubMed 
    involved_in serotonin uptake  
    involved_in serotonin uptake PubMed 
    involved_in serotonin uptake  
    involved_in somato-dendritic dopamine secretion PubMed 
    involved_in xenobiotic transport  
    Items 1 - 25 of 42
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    located_in axon PubMed 
    located_in axon terminus PubMed 
    located_in cell body PubMed 
    located_in cell projection PubMed 
    located_in centrosome  
    located_in centrosome  
    located_in dendrite PubMed 
    located_in dense core granule PubMed 
    is_active_in dopaminergic synapse PubMed 
    located_in dopaminergic synapse  
    is_active_in dopaminergic synapse  
    located_in intracellular membrane-bounded organelle  
    located_in neuronal cell body PubMed 
    is_active_in neuronal dense core vesicle PubMed 
    is_active_in neuronal dense core vesicle membrane PubMed 
    is_active_in postsynapse PubMed 
    located_in secretory granule membrane PubMed 
    located_in synaptic vesicle PubMed 
    is_active_in synaptic vesicle membrane  
    is_active_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane  
    located_in synaptic vesicle membrane  
    is_active_in terminal bouton  
    located_in terminal bouton PubMed 
    Items 1 - 20 of 25

    General protein information

    Preferred Names
    synaptic vesicular amine transporter
    Names
    Solute carrier family 18 A2 (vesicular monoamine transporter 2)
    VAT2
    monoamine transporter
    solute carrier family 18 (vesicular monoamine transporter), member 2
    solute carrier family 18 (vesicular monoamine), member 2
    solute carrier family 18 member 2
    vesicular amine transporter 2
    vesicular monoamine transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013031.2NP_037163.1  synaptic vesicular amine transporter

      See identical proteins and their annotated locations for NP_037163.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q01827, Q9QVP1
      UniProtKB/TrEMBL
      A0A0G2JSJ6, A6JI82
      Related
      ENSRNOP00000011983.1, ENSRNOT00000011983.4
      Conserved Domains (1) summary
      cd17384
      Location:124472
      MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      268399815..268435229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231664.5XP_006231726.1  synaptic vesicular amine transporter isoform X1

      See identical proteins and their annotated locations for XP_006231726.1

      UniProtKB/Swiss-Prot
      Q01827, Q9QVP1
      UniProtKB/TrEMBL
      A0A0G2JSJ6, A6JI82
      Conserved Domains (1) summary
      cd17384
      Location:124472
      MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily
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