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    Scd stearoyl-CoA desaturase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246074, updated on 4-Jan-2025

    Summary

    Official Symbol
    Scdprovided by RGD
    Official Full Name
    stearoyl-CoA desaturaseprovided by RGD
    Primary source
    RGD:621176
    See related
    EnsemblRapid:ENSRNOG00000013552 AllianceGenome:RGD:621176
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Scd1
    Summary
    Enables iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in response to fatty acid; response to nutrient; and unsaturated fatty acid biosynthetic process. Located in membrane. Used to study carcinoma. Biomarker of hyperinsulinism; metabolic dysfunction-associated steatohepatitis; and metabolic dysfunction-associated steatotic liver disease. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 4781.4), Adrenal (RPKM 4523.2) and 5 other tissues See more
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    Genomic context

    See Scd in Genome Data Viewer
    Location:
    1q54
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (253218968..253232101, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (243269745..243282878, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (264159966..264173061, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene stearoyl-Coenzyme A desaturase 2 Neighboring gene stearoyl-coenzyme A desaturase 4 Neighboring gene 5S ribosomal RNA Neighboring gene Wnt family member 8B Neighboring gene SEC31 homolog B, COPII coat complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables iron ion binding  
    enables iron ion binding PubMed 
    enables iron ion binding  
    enables metal ion binding  
    enables oxidoreductase activity PubMed 
    enables oxidoreductase activity  
    enables palmitoyl-CoA 9-desaturase activity  
    enables palmitoyl-CoA 9-desaturase activity  
    enables stearoyl-CoA 9-desaturase activity  
    enables stearoyl-CoA 9-desaturase activity PubMed 
    enables stearoyl-CoA 9-desaturase activity PubMed 
    enables stearoyl-CoA 9-desaturase activity  
    enables stearoyl-CoA 9-desaturase activity PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation  
    acts_upstream_of_or_within defense response to Gram-positive bacterium  
    acts_upstream_of_or_within fatty acid biosynthetic process  
    involved_in fatty acid biosynthetic process PubMed 
    involved_in lipid biosynthetic process PubMed 
    acts_upstream_of_or_within lipid homeostasis  
    involved_in monounsaturated fatty acid biosynthetic process  
    acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process  
    involved_in monounsaturated fatty acid biosynthetic process  
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    acts_upstream_of_or_within response to bacterium  
    involved_in response to fatty acid  
    involved_in response to fatty acid PubMed 
    involved_in response to nutrient PubMed 
    involved_in sebaceous gland development  
    involved_in sterol homeostasis  
    involved_in tarsal gland development  
    involved_in triglyceride metabolic process  
    involved_in unsaturated fatty acid biosynthetic process  
    involved_in unsaturated fatty acid biosynthetic process PubMed 
    involved_in unsaturated fatty acid biosynthetic process PubMed 
    involved_in unsaturated fatty acid biosynthetic process  
    acts_upstream_of_or_within white fat cell differentiation  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in membrane PubMed 
    located_in membrane  
    located_in nucleolus  

    General protein information

    Preferred Names
    acyl-CoA desaturase 1
    Names
    delta(9)-desaturase 1
    fatty acid desaturase 1
    stearoyl-CoA desaturase 1
    stearoyl-Coenzyme A desaturase 1
    NP_631931.2
    XP_006231495.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139192.2NP_631931.2  acyl-CoA desaturase 1

      See identical proteins and their annotated locations for NP_631931.2

      Status: PROVISIONAL

      Source sequence(s)
      AF509569
      UniProtKB/Swiss-Prot
      P07308, Q8JZL5
      UniProtKB/TrEMBL
      A6JHF3, A6JHF9
      Related
      ENSRNOP00000018447.3, ENSRNOT00000018447.7
      Conserved Domains (2) summary
      cd03505
      Location:99336
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:100305
      FA_desaturase; Fatty acid desaturase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      253218968..253232101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231433.3XP_006231495.1  acyl-CoA desaturase 1 isoform X1

      See identical proteins and their annotated locations for XP_006231495.1

      UniProtKB/Swiss-Prot
      P07308, Q8JZL5
      UniProtKB/TrEMBL
      A6JHF3, A6JHF9
      Conserved Domains (2) summary
      cd03505
      Location:99336
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:100305
      FA_desaturase; Fatty acid desaturase
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