Calcb calcitonin-related polypeptide, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Calcbprovided by RGD
Official Full Name: calcitonin-related polypeptide, betaprovided by RGD
Primary source: RGD:620997
See related: EnsemblRapid:ENSRNOG00000011074 AllianceGenome:RGD:620997
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CGRP2; CGRP-II
Summary: Predicted to enable calcitonin receptor binding activity and hormone activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; calcitonin gene-related peptide receptor signaling pathway; and regulation of cytosolic calcium ion concentration. Predicted to be active in extracellular space. Orthologous to human CALCB (calcitonin related polypeptide beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 35.2), Brain (RPKM 4.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (178399634..178404654)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (168965383..168970259)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (184271116..184276480)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that calcitonin gene-related peptide-B receptors are present in rat placenta and that receptor levels are higher with gestational age and lower at term labor (Calcb)
Title: Expression and regulation of calcitonin gene-related Peptide receptor in rat placentas.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcitonin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcitonin gene-related peptide receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcitonin gene-related peptide 2

Names: beta-type CGRP; calcitonin gene-related peptide II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429731.1 → NP_001416660.1 calcitonin gene-related peptide 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_138513.3 → NP_612522.3 calcitonin gene-related peptide 2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P10093

UniProtKB/TrEMBL

A6I8C0