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    Btbd8 BTB domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100364240, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Btbd8provided by RGD
    Official Full Name
    BTB domain containing 8provided by RGD
    Primary source
    RGD:2321418
    See related
    EnsemblRapid:ENSRNOG00000023446 AllianceGenome:RGD:2321418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in synaptic vesicle budding from endosome and synaptic vesicle endocytosis. Located in neuron projection terminus and synaptic vesicle. Part of AP-2 adaptor complex. Orthologous to human BTBD8 (BTB domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 143.1), Lung (RPKM 25.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btbd8 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (2410093..2483114, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (2265187..2338426, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (3282422..3351740, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II associated protein 2 Neighboring gene glomulin, FKBP associated protein Neighboring gene similar to human chromosome 1 open reading frame 146 Neighboring gene uncharacterized LOC108352691 Neighboring gene lysophosphatidylcholine acyltransferase 2b Neighboring gene epoxide hydrolase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development. Piccini A, et al. Cell Rep, 2017 Dec 19. PMID 29262337
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in synaptic vesicle budding from endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bTB/POZ domain-containing protein 8
    Names
    AP2-interacting clathrin-endocytosis protein
    APache
    BTB (POZ) domain containing 8
    BTB/POZ domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419526.1 → NP_001406455.1  bTB/POZ domain-containing protein 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      A0A452Q762, D4A0X3
      Related
      ENSRNOP00000038747.5, ENSRNOT00000037931.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      2410093..2483114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092624.2 → XP_038948552.1  bTB/POZ domain-containing protein 8 isoform X2

      Conserved Domains (4) summary
      cd18285
      Location:43 → 146
      BTB1_POZ_BTBD8; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      cd18286
      Location:189 → 308
      BTB2_POZ_BTBD8; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      cd18490
      Location:316 → 377
      BACK_BTBD8; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      pfam15363
      Location:1724 → 1768
      DUF4596; Domain of unknown function (DUF4596)

    2. XM_039092625.2 → XP_038948553.1  bTB/POZ domain-containing protein 8 isoform X4

      Conserved Domains (4) summary
      cd18285
      Location:1 → 91
      BTB1_POZ_BTBD8; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      cd18286
      Location:134 → 253
      BTB2_POZ_BTBD8; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      cd18490
      Location:261 → 322
      BACK_BTBD8; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      pfam15363
      Location:1670 → 1714
      DUF4596; Domain of unknown function (DUF4596)

    3. XM_039092627.2 → XP_038948555.1  bTB/POZ domain-containing protein 8 isoform X5

      Conserved Domains (3) summary
      cd18285
      Location:43 → 146
      BTB1_POZ_BTBD8; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      cd18286
      Location:189 → 308
      BTB2_POZ_BTBD8; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      cd18490
      Location:316 → 377
      BACK_BTBD8; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8)

    4. XM_006250597.5 → XP_006250659.2  bTB/POZ domain-containing protein 8 isoform X3

      Conserved Domains (5) summary
      smart00225
      Location:206 → 294
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14821
      Location:405 → 452
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00651
      Location:195 → 299
      BTB; BTB/POZ domain
      pfam15363
      Location:1707 → 1748
      DUF4596; Domain of unknown function (DUF4596)
      cl02518
      Location:51 → 125
      BTB; BTB/POZ domain

    5. XM_063272796.1 → XP_063128866.1  bTB/POZ domain-containing protein 8 isoform X6

    6. XM_039092623.2 → XP_038948551.1  bTB/POZ domain-containing protein 8 isoform X1

      Conserved Domains (4) summary
      cd18285
      Location:43 → 146
      BTB1_POZ_BTBD8; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      cd18286
      Location:189 → 308
      BTB2_POZ_BTBD8; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      cd18490
      Location:316 → 377
      BACK_BTBD8; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      pfam15363
      Location:1725 → 1769
      DUF4596; Domain of unknown function (DUF4596)

    7. XM_039092626.2 → XP_038948554.1  bTB/POZ domain-containing protein 8 isoform X4

      Conserved Domains (4) summary
      cd18285
      Location:1 → 91
      BTB1_POZ_BTBD8; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      cd18286
      Location:134 → 253
      BTB2_POZ_BTBD8; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      cd18490
      Location:261 → 322
      BACK_BTBD8; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
      pfam15363
      Location:1670 → 1714
      DUF4596; Domain of unknown function (DUF4596)

    8. XM_039092629.2 → XP_038948557.1  bTB/POZ domain-containing protein 8 isoform X7

      Conserved Domains (2) summary
      pfam15363
      Location:1388 → 1432
      DUF4596; Domain of unknown function (DUF4596)
      cl28903
      Location:4 → 40
      BACK; BACK (BTB and C-terminal Kelch) domain

    9. XM_063272799.1 → XP_063128869.1  bTB/POZ domain-containing protein 8 isoform X10

      UniProtKB/TrEMBL
      A6KPJ4

    10. XM_063272798.1 → XP_063128868.1  bTB/POZ domain-containing protein 8 isoform X9

      UniProtKB/TrEMBL
      A6KPJ4

    11. XM_039092630.2 → XP_038948558.1  bTB/POZ domain-containing protein 8 isoform X8

      UniProtKB/TrEMBL
      A6KPJ4
      Conserved Domains (1) summary
      pfam15363
      Location:1189 → 1233
      DUF4596; Domain of unknown function (DUF4596)

    12. XM_063272797.1 → XP_063128867.1  bTB/POZ domain-containing protein 8 isoform X8

      UniProtKB/TrEMBL
      A6KPJ4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A0X3.4 GenPept UniProtKB/Swiss-Prot:D4A0X3

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